Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal
0.400 Biomarker phenotype BEFREE Intrathecal delivery of a cell-penetrating fusion peptide corresponding to the Cdk5 phosphorylation site in AP2μ2, which competed with AP2μ2 for phosphorylation by Cdk5, increased the abundance of TRPV1 on the surface of dorsal root ganglion neurons and reduced complete Freund's adjuvant (CFA)-induced inflammatory thermal hyperalgesia in rats. 31186372 2019
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal
0.400 AlteredExpression phenotype BEFREE The present results suggested that TNF-α could sensitize TRPV1 by promoting its expression, thus leading to mechanical allodynia and thermal hyperalgesia in vincristine-treated rats. 29552137 2018
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal
0.400 Biomarker phenotype BEFREE Methods We investigated the functional roles of TRPM8 and TRPV1 in a meningeal inflammation-based migraine model by measuring the effects of facial TRPM8 activation on thermal allodynia and assessing receptor coexpression changes in TG neurons. 28554243 2018
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal
0.400 AlteredExpression phenotype BEFREE The transient receptor potential vanilloid type 1 (TRPV1) receptor is a polymodal molecular integrator in the pain pathway expressed in Aδ- and C-fibre nociceptors and is responsible for the thermal hyperalgesia associated with inflammatory pain. 28094445 2017
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal
0.400 PosttranslationalModification phenotype BEFREE Together, these results demonstrate that Cdk5-mediated phosphorylation of TRPV1 at Thr-406 increases the surface level and the function of TRPV1, while the TAT-T406 peptide can effectively attenuate thermal hyperalgesia. 26376215 2015
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal
0.400 Biomarker phenotype BEFREE Thus, the direct anchoring of both PKA and AC to TRPV1 by AKAP79/150 facilitates the response to inflammatory mediators and may be critical in the pathogenesis of thermal hyperalgesia. 23264624 2013
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal
0.400 Biomarker phenotype BEFREE Although it is known that sensitization of the heat transducer TRPV1 largely subserves thermal hyperalgesia, the cellular mechanisms underlying mechanical hyperalgesia have been elusive. 22921401 2012
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal
0.400 Biomarker phenotype CTD_human The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. 23006841 2012
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal
0.400 Biomarker phenotype CTD_human Because animals treated with opiates show thermal hyperalgesia, we examined the possible role of TRPV1 receptors in the development of morphine-induced hyperalgesia using TRPV1 wild-type (WT) and knock-out (KO) mice and with administration of a TRPV1 antagonist in mice and rats. 18774343 2009
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal
0.400 Biomarker phenotype BEFREE Coadministration of the cyclooxygenase inhibitor, ibuprofen, with the TRPV1 antagonist decreased inflammatory thermal hyperalgesia in transgenic but not wild-type animals. 19091963 2008
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal
0.400 Biomarker phenotype BEFREE Consistent with this model, TRPV1 knock-out mice are devoid of post-inflammatory thermal hyperalgesia. 18209521 2008
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal
0.400 Biomarker phenotype CTD_human Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation. 18234885 2008
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal
0.400 Biomarker phenotype BEFREE Furthermore, intraplantar or intrathecal administration of A-784168 blocked CFA-induced thermal hyperalgesia, suggesting that both peripheral and CNS TRPV1 receptors may play a role in inflammatory thermal hyperalgesia. 16971522 2006
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal
0.400 Biomarker phenotype BEFREE To test this hypothesis, CCR1 was cotransfected into human embryonic kidney (HEK)293 cells together with transient receptor potential vanilloid 1 (TRPV1), a cation channel required for certain types of thermal hyperalgesia. 15764707 2005
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal
0.400 Biomarker phenotype CTD_human Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception. 12151517 2002