Disease: Mechanical Allodynia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.400 Biomarker phenotype BEFREE <b>Conclusions</b>: Knockdown of TRPV1 effectively ameliorated mechanical allodynia and thermal hyperalgesia induced by TCI. 31296147 2019
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.400 Biomarker phenotype BEFREE We further found that TASK-3-containing channels anatomically define a unique population of small-sized, transient receptor potential cation channel subfamily M member 8 (TRPM8)-, transient receptor potential cation channel subfamily V member 1 (TRPV1)-, or tyrosine hydroxylase (TH)-positive nociceptive sensory neurons and functionally regulate their membrane excitability, supporting CHET3 analgesic effects in thermal hyperalgesia and mechanical allodynia under chronic pain. 31748231 2019
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.400 Biomarker phenotype BEFREE The TRPV1 antagonist capsazepine, the selective TRPV4 antagonist HC-067047 and the calcium ions inhibitor ruthenium red were used to treat thermal and/or mechanical hyperalgesia. 29637027 2018
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.400 Biomarker phenotype BEFREE Similarly, NTG injection produced significant hindpaw mechanical allodynia or facial cold allodynia, but not heat hyperalgesia in transient receptor potential type V1 (TRPV1) knockout mice. 29187670 2018
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.400 AlteredExpression phenotype BEFREE HU mice appear to be a useful model for immobility-induced osteoporotic pain and hindlimb-unloading-induced bone loss, as well as upregulation of CGRP and TRPV1 expressions in DRG neurons, and BP treatment prevented bone loss and mechanical hyperalgesia. 30431005 2018
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.400 Biomarker phenotype BEFREE Similarly, TRPV1 deficient mice showed a pronounced reduction in mechanical allodynia to paclitaxel acute injection and did not develop heat hypersensitivity. 29577893 2018
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.400 Biomarker phenotype BEFREE Endothelin-1 elicits directly TRPA1- and TRPV1-mediated mechanical allodynia via both ET<sub>A</sub> and ET<sub>B</sub> receptors on nociceptive fibers. 29518348 2018
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.400 AlteredExpression phenotype BEFREE The present results suggested that TNF-α could sensitize TRPV1 by promoting its expression, thus leading to mechanical allodynia and thermal hyperalgesia in vincristine-treated rats. 29552137 2018
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.400 Biomarker phenotype BEFREE To analyze the contribution of TRPV1 to the development of vincristine-induced mechanical allodynia/hyperalgesia, TRPV1 expression in the rat dorsal root ganglion (DRG) was analyzed after vincristine treatment. 28410966 2017
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.400 Biomarker phenotype BEFREE TRPV1 was responsible from the cisplatin-induced heat hyperalgesia and mechanical allodynia in the sensory neurons. 29326595 2017
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.400 Biomarker phenotype BEFREE Furthermore, E2 potentiated the TRPV1 receptor activation-induced mechanical hyperalgesia in OVX mice. 28977586 2017
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.400 AlteredExpression phenotype BEFREE ALN prevented ovariectomy-induced bone loss and mechanical hyperalgesia in hindlimbs, and it suppressed TRPV1 and CGRP expressions in DRG neurons. 28258808 2017
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.400 Biomarker phenotype CTD_human The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. 23006841 2012
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.400 Biomarker phenotype CTD_human TRPV1 receptor in expression of opioid-induced hyperalgesia. 18774343 2009
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.400 Biomarker phenotype CTD_human Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation. 18234885 2008
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.400 Biomarker phenotype CTD_human Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception. 12151517 2002