VWF, von Willebrand factor, 7450

N. diseases: 498; N. variants: 158
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker disease BEFREE Endothelial surface and circulating glycoprotein von Willebrand factor (vWF) regulates platelet adhesion and is associated with thrombotic diseases, including ischemic stroke, myocardial infarction, and peripheral vascular disease. 30987839 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction. 30366922 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker disease BEFREE Furthermore, compared with the MI group, the plasma levels of TXA2, ET-1 and vWF contents signififi cantly decreased in the MI+SSYX group, and the ET-1 mRNA expression levels of myocardium in the border zone significantly decreased, and the VEGF, PGI2 and eNOS mRNA expression levels signififi cantly increased (all P<0.05). 30656600 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 AlteredExpression disease BEFREE A reduced plasma ADAMTS13 activity and increased VWF levels are associated with a higher risk of myocardial infarction. 30471507 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker disease BEFREE ApoA-I, HDL-C, and inflammatory markers (C-reactive protein [CRP], serum amyloid A (SAA), fibrinogen, von Willebrand factor [vWF], and D-dimer) were measured from blood samples of 1028 patients drawn 2 months after an index myocardial infarction (MI). 28391888 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 AlteredExpression disease BEFREE During the 2-month interval prior to an event, cases (n = 48) had higher levels of the vWF and ADAMTS13 than controls (n = 95; P = .05), but significance was lost after adjusting for the baseline differences in myocardial infarction, unstable angina, and stroke. 27317583 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker disease BEFREE Moreover, experimental mouse models of ischemic stroke and myocardial infarction have further supported VWF as a potential therapeutic target. 26771163 2016
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 AlteredExpression disease BEFREE It is well established that high plasma von Willebrand factor (VWF) levels are associated with an increased risk of arterial thrombosis, including myocardial infarction and ischemic stroke. 21342431 2011
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker disease RGD Effects of Radix et Rhizoma Rhodiolae Kirilowii on expressions of von Willebrand factor, hypoxia-inducible factor 1 and vascular endothelial growth factor in myocardium of rats with acute myocardial infarction. 19435557 2009
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 AlteredExpression disease BEFREE High plasma levels of beta2-glycoprotein I remained protective for myocardial infarction despite high levels of VWF. 19706887 2009
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker disease LHGDN Evidence that high von Willebrand factor and low ADAMTS-13 levels independently increase the risk of a non-fatal heart attack. 18194418 2008
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease LHGDN The G/A polymorphism of the von Willebrand factor gene failed to show any association with MI or coronary atherosclerosis in this series of men. 17619827 2008
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE The G/A polymorphism of the von Willebrand factor gene failed to show any association with MI or coronary atherosclerosis in this series of men. 17619827 2008
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker disease LHGDN ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men. 17053057 2007
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE We examined the effect of G894T polymorphism on endothelial function, on markers of endothelial cells injury and activation such as von Willebrand factor (vWF) and on serum levels of proinflammatory cytokines such as interleukins 6 (IL-6) and 1b (IL-1b), in young myocardial infarction (MI) survivors. 16337503 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE The thrombospondin-1 N700S polymorphism is associated with early myocardial infarction without altering von Willebrand factor multimer size. 16684956 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE G894T polymorphism on the eNOS gene increases the risk for premature MI and modifies the response of vascular endothelium during the acute phase of MI by affecting the release of vWF, IL-6, and oxidative stress status, an effect diminished one year after the event. 16168297 2005
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE We conducted this genetic study to test whether the ABO O1 allele is associated with low vWF plasma levels and with a reduced risk of MI. 15166945 2004
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE We assessed the contribution of classical cardiovascular risk factors (dyslipidaemia, hypertension, and prior myocardial infarction), and of new cardiovascular risk factors (microalbuminuria, von Willebrand factor, sVCAM-1 and C-reactive protein) to the mortality risk during nearly 10 years of follow up. 12534452 2002
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 GeneticVariation disease BEFREE The -1185 A/G and -1051 G/A dimorphisms in the von Willebrand factor gene promoter and risk of myocardial infarction. 11736957 2001