|
Mental disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The nucleus accumbens (NAc) is part of a brain reward circuit affected by Δ<sup>9</sup>-THC through modulation of glutamate afferents arising from corticolimbic brain areas implicated in drug addiction and psychiatric disorders.
|
31543247 |
2020 |
|
Drug Dependence
|
0.010 |
Biomarker
|
group |
BEFREE |
The nucleus accumbens (NAc) is part of a brain reward circuit affected by Δ<sup>9</sup>-THC through modulation of glutamate afferents arising from corticolimbic brain areas implicated in drug addiction and psychiatric disorders.
|
31543247 |
2020 |
|
Anorexia Nervosa
|
0.010 |
Biomarker
|
disease |
BEFREE |
Δ<sup>9</sup>-THC is an approved therapeutic treatment for a range of conditions, including chronic pain, chemotherapy-induced nausea and vomiting, and multiple sclerosis, and is being investigated in indications such as anorexia nervosa, agitation in dementia, and Tourette's syndrome.
|
30689342 |
2019 |
|
Cannabis Dependence
|
0.010 |
Biomarker
|
disease |
BEFREE |
The Cerebellum, THC, and Cannabis Addiction: Findings from Animal and Human Studies.
|
30610540 |
2019 |
|
Headache
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We sought to determine whether inhalation of cannabis decreases headache and migraine ratings as well as whether gender, type of cannabis (concentrate vs. flower), THC, CBD, or dose contribute to changes in these ratings.
|
31715263 |
2019 |
|
Gilles de la Tourette syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Δ<sup>9</sup>-THC is an approved therapeutic treatment for a range of conditions, including chronic pain, chemotherapy-induced nausea and vomiting, and multiple sclerosis, and is being investigated in indications such as anorexia nervosa, agitation in dementia, and Tourette's syndrome.
|
30689342 |
2019 |
|
Migraine Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We sought to determine whether inhalation of cannabis decreases headache and migraine ratings as well as whether gender, type of cannabis (concentrate vs. flower), THC, CBD, or dose contribute to changes in these ratings.
|
31715263 |
2019 |
|
Drug usage
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
For parents with hair concentrations in the typical range of regular drug use, the drug was detected in children hair with the following frequency: methadone 65.5%, heroin (6-AM) 63.6%, cocaine 92.1%, amphetamine 80%, MDMA 42.9% and THC 67.4% with higher percentage for younger children.
|
30831411 |
2019 |
|
Physical addiction
|
0.010 |
Biomarker
|
disease |
BEFREE |
The time-related increase in home-cage activity upon abrupt discontinuation of chronic Δ9-THC treatment, as well as the effects of rimonabant to increase activity in monkeys receiving chronic, but not intermittent, Δ9-THC treatment, are consistent with signs of physical dependence on Δ9-THC in primates.
|
30861005 |
2019 |
|
Fibrotic lymphadenopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Gomori one-step trichrome staining detected significant collagen deposition (fibrosis) in the paracortex and B cell follicular zones of axillary lymph nodes from all VEH/SIV but not in THC/SIV rhesus macaques, thus demonstrating the ability of Δ<sup>9</sup>-THC to prevent lymph node fibrosis, a serious irreversible consequence of HIV induced chronic inflammation.
|
31114576 |
2019 |
|
Cancer Pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Of the nine studies reviewed, eight reviewed the effect of the cannabinoid THC on cancer pain, and one study reviewed the use of medicinally available whole plant cannabis.
|
30527857 |
2019 |
|
Drug Resistant Epilepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The therapeutic applications of Δ<sup>9</sup>-THC are limited, whereas cannabidiol (CBD), another phytocannabinoid, induces antiepileptic effects in experimental animals and in patients with refractory epilepsies.
|
31839498 |
2019 |
|
Adult Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the absence of WASP, active GTP-bound CDC42 was increased and the genetic deletion of one CDC42 allele was sufficient to impair lymphoma growth.
|
30510251 |
2019 |
|
Childhood Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the absence of WASP, active GTP-bound CDC42 was increased and the genetic deletion of one CDC42 allele was sufficient to impair lymphoma growth.
|
30510251 |
2019 |
|
Nausea and vomiting
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Synthetic THC analogue (nabilone) is approved for chemotherapy-associated nausea and vomiting refractory to conventional treatment in four EFIC chapters'.
|
29134767 |
2018 |
|
Sexually Transmitted Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Participants in the SRRI + ETOH + THC intervention had lower incidence of STI at follow-up (3.9%) than those in either the SRRI (12.4%; odds ratio, 0.29; 95% CI, 0.10-0.84) or the SRRI + ETOH (10.2%; odds ratio, 0.36; 95% CI, 0.12-1.05) interventions.
|
29435591 |
2018 |
|
Caffeine related disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Using genetic and candidate gene approaches, we show that among a variety of protein, Wls interacts with the dopamine transporter (target of cocaine), cannabinoid receptors (target of THC), Adenosine A2A receptor (target of caffeine), and SGIP1 (endocytic regulator of cannabinoid receptors).
|
28734904 |
2018 |
|
Alcohol or Other Drugs use
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients testing positive for THC-COOH had a shorter length of stay compared to patients testing negative for THC-COOH, after adjusting for age, prior psychiatric admissions, history of a psychotic-spectrum disorder, and comorbid additional substance use (p = 0.02).
|
28613973 |
2018 |
|
Solid Neoplasm
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We found that p53<sup>+/-</sup>WASp<sup>+</sup> mice developed malignancies, including solid tumors and T cell lymphomas with 71.4% of survival 24 weeks after irradiation. p53<sup>+/-</sup>WASp<sup>-</sup> mice showed lower survival rate and developed various early onset malignancies.
|
30393584 |
2018 |
|
Malignant neoplasm of pancreas
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
WAVE2 is a member of the WASP/WAVE family of actin cytoskeletal regulatory proteins; unfortunately, little is known about its function in pancreatic cancers.
|
30353690 |
2018 |
|
Juvenile Myelomonocytic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This is the first study to associate somatically acquired WASP mutations with a hematopoietic malignancy and increases insight in the complexity of the genomic landscape of JMML that shows low recurrent mutations concomitant with general hyperactivation of RAS pathway signaling.
|
29316027 |
2018 |
|
Hyperactive behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We provide molecular evidence that the hyperactivity of XLN neutrophils is caused by WASp in a constitutively open conformation due to contingent phosphorylation of the critical tyrosine-293 and plasma membrane localization.
|
30124469 |
2018 |
|
Agnosia for Pain
|
0.010 |
Biomarker
|
disease |
BEFREE |
Healthy cannabis smokers (N = 18) were administered oxycodone (0, 2.5, and 5.0 mg, PO) with smoked cannabis (0.0, 5.6% Δ<sup>9</sup> tetrahydrocannabinol [THC]) and analgesia was assessed using the Cold-Pressor Test (CPT).
|
29463913 |
2018 |
|
Psychotic symptom
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
However, Δ9-THC-induced psychotic symptoms and attentional salience behavioral impairment were more pronounced in NUs compared with CUs (all ps ≤ .04).
|
30138003 |
2018 |
|
Overactive Bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
The THC/CBD treatment successfully reduced the OAB symptoms (p = 0.001).
|
29052091 |
2018 |