Wolf-Hirschhorn Syndrome
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we propose that overexpression of candidate genes in WHS (WHSC1, WHSC2 and LETM1) due to a duplication causes a clinical entity different to both the WHS and 4p trisomy syndrome.
|
19729912 |
2009 |
Wolf-Hirschhorn Syndrome
|
0.330 |
Biomarker
|
disease |
BEFREE |
The microduplication did not involve WHSC1 and WHSC2 which are considered in the critical region for WHS and trisomy 4p.
|
21815251 |
2011 |
Wolf-Hirschhorn Syndrome
|
0.330 |
Biomarker
|
disease |
BEFREE |
Employing a unique panel of patient-derived cell lines with differing-sized 4p deletions, we provide evidence that haploinsufficiency of SLBP and/or WHSC2 (NELF-A) contributes to several novel cellular phenotypes of WHS, including delayed progression from S-phase into M-phase, reduced DNA replication in asynchronous culture and altered higher order chromatin assembly.
|
22328085 |
2012 |
Squamous cell carcinoma of esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our results confirmed the critical role of the non-coding function of NELFA mRNA in ESCC tumorigenesis and indicated that NELFA mRNA can be regarded as a therapeutic target and an independent prognostic indicator in ESCC patients.
|
31845510 |
2020 |
Carcinogenesis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Taken together, our results confirmed the critical role of the non-coding function of NELFA mRNA in ESCC tumorigenesis and indicated that NELFA mRNA can be regarded as a therapeutic target and an independent prognostic indicator in ESCC patients.
|
31845510 |
2020 |
Trisomy 4p
|
0.010 |
Biomarker
|
disease |
BEFREE |
The microduplication did not involve WHSC1 and WHSC2 which are considered in the critical region for WHS and trisomy 4p.
|
21815251 |
2011 |
Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
Arachnodactyly
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Ataxia
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Blepharoptosis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Cleft upper lip
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Cleft Palate
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Congenital clubfoot
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Cryptorchidism
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Exophthalmos
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Failure to Thrive
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Fetal Growth Retardation
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Atrial Septal Defects
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
Hemangioma
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Orbital separation excessive
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Hypodontia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Kyphosis deformity of spine
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Microcephaly
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Micrognathism
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Movement Disorders
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|