|
Mammary Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
GPNMB augments Wnt-1 mediated breast tumor initiation and growth by enhancing PI3K/AKT/mTOR pathway signaling and β-catenin activity.
|
30914799 |
2019 |
|
Mammary Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we used mouse mammary tumor virus (MMTV)-Wnt1 transgenic mice, which develop aggressive mammary adenocarcinomas, to examine whether Limb-Bud-and-Heart (LBH) - a WNT/β-catenin target transcription co-factor overexpressed in human triple-negative breast cancers with WNT pathway hyperactivation, contributes to WNT-induced tumorigenesis.
|
30509497 |
2019 |
|
Mammary Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
After identifying TICs in spontaneous breast tumors of the MMTV-Wnt1 mouse model, we confirmed the specific expression and activation of Yes-associated protein 1 (Yap1) within TICs.
|
26695440 |
2016 |
|
Mammary Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we evaluated mammary tumor response to doxorubicin in female mouse mammary tumor virus-Wnt1 transgenic offspring exposed to a metabolically compromised environment imposed by maternal high-fat diet.
|
27402613 |
2016 |
|
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Collectively, these results suggest that Wnt1 expression may give rise to the properties of CSCs in breast tumors.
|
22846569 |
2012 |
|
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, analysis of leptin-treated breast tumors shows increased expression of Wnt1, pGSK3β, and vimentin along with higher nuclear accumulation of β-catenin and reduced E-cadherin expression providing in vivo evidence for a previously unrecognized cross-talk between leptin and MTA1/Wnt signaling in epithelial-mesenchymal transition of breast cancer cells.
|
22270359 |
2012 |
|
Mammary Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cooperative signaling between Wnt1 and integrin-linked kinase induces accelerated breast tumor development.
|
20565980 |
2010 |
|
Mammary Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Previously, we found that p53 genotype was correlated with ER expression and response to tamoxifen in mammary tumors arising in mouse mammary tumor virus-Wnt-1 transgenic mice.
|
19351845 |
2009 |
|
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Silencing of Wnt-1 by siRNA induces apoptosis of MCF-7 human breast cancer cells.
|
18059186 |
2008 |
|
Mammary Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MMTV-Wnt-1 breast tumors were harvested, dissociated into single-cell suspensions, and sorted by flow cytometry on Thy1, CD24, and CD45.
|
17975224 |
2008 |
|
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These observations suggest that Wnt-1 is dominant over Neu in specifying mammary tumor expression profiles.
|
17121432 |
2006 |
|
Mammary Neoplasms
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Suppression of Wnt signaling by the green tea compound (-)-epigallocatechin 3-gallate (EGCG) in invasive breast cancer cells. Requirement of the transcriptional repressor HBP1.
|
16495219 |
2006 |
|
Mammary Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Wnt-1 transgenic mice harboring a knock-out of ERalpha provides a means of examining the effect of estrogen deprivation in the absence of the ER in animals with a high incidence of breast tumors.
|
14623547 |
2003 |
|
Mammary Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Although WNT1 itself has not been implicated in human breast neoplasms, it has been reported that other WNT genes are sometimes overexpressed in human breast cancer and there is growing evidence that downstream components of the Wnt signaling pathway are activated in a significant proportion of breast tumors.
|
11737884 |
2001 |