|
Autistic Disorder
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
We previously reported that the WNT2 gene located on 7q31 was associated with the risk of autism.
|
22522212 |
2012 |
|
Autistic Disorder
|
0.370 |
Biomarker
|
disease |
BEFREE |
There was no association with autism for 17 tag SNPs of WNT2, EN2, SHANK3, and FOXP2 based on SNP analyses.
|
21575668 |
2011 |
|
Autistic Disorder
|
0.370 |
Biomarker
|
disease |
BEFREE |
Considering the important role of the WNT2 gene in brain development, our results therefore indicate that the WNT2 gene is one of the strong candidate genes for autism.
|
19895723 |
2010 |
|
Autistic Disorder
|
0.370 |
Biomarker
|
disease |
CTD_human |
Considering the important role of the WNT2 gene in brain development, our results therefore indicate that the WNT2 gene is one of the strong candidate genes for autism.
|
19895723 |
2010 |
|
Autistic Disorder
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
A reported association between autism and deletions of WNT2, a gene also deleted in our patient, is likewise not supported by our case.
|
17330859 |
2007 |
|
Autistic Disorder
|
0.370 |
GeneticVariation
|
disease |
LHGDN |
Our interpretation of these findings is that it is unlikely that DNA variations in RELN and WNT2 play a significant role in the genetic predisposition to autism.
|
15048648 |
2004 |
|
Autistic Disorder
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Our interpretation of these findings is that it is unlikely that DNA variations in RELN and WNT2 play a significant role in the genetic predisposition to autism.
|
15048648 |
2004 |
|
Autistic Disorder
|
0.370 |
Biomarker
|
disease |
BEFREE |
However, differences in allele frequencies of the 3' UTR single nucleotide polymorphism between the present population and that of Wassink et al. may account for the inability to detect association between WNT2 and autistic disorder in the present data set.
|
11840514 |
2002 |
|
Autistic Disorder
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Based on these findings, we hypothesize that rare mutations occur in the WNT2 gene that significantly increase susceptibility to autism even when present in single copies, while a more common WNT2 allele (or alleles) not yet identified may exist that contributes to the disorder to a lesser degree.
|
11449391 |
2001 |
|
Autistic Disorder
|
0.370 |
Biomarker
|
disease |
CTD_human |
Based on these findings, we hypothesize that rare mutations occur in the WNT2 gene that significantly increase susceptibility to autism even when present in single copies, while a more common WNT2 allele (or alleles) not yet identified may exist that contributes to the disorder to a lesser degree.
|
11449391 |
2001 |
|
cervical cancer
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
WNT2 expression level in cervical cancer was detected using western blotting, quantitative PCR, and immunohistochemistry.
|
27513465 |
2016 |
|
Uterine Cervical Neoplasm
|
0.310 |
Biomarker
|
disease |
CTD_human |
Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells.
|
25061499 |
2014 |
|
cervical cancer
|
0.310 |
Biomarker
|
disease |
CTD_human |
Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells.
|
25061499 |
2014 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
BEFREE |
The present study does not support a major role for WNT2 in schizophrenia.
|
20492734 |
2010 |
|
Uterine Cervical Neoplasm
|
0.310 |
Biomarker
|
disease |
LHGDN |
Substantial changes in gene expression of Wnt, MAPK and TNFalpha pathways induced by TGF-beta1 in cervical cancer cell lines.
|
15878915 |
2005 |
|
Visual seizure
|
0.200 |
Biomarker
|
disease |
RGD |
Chronic electroconvulsive seizure up-regulates beta-catenin expression in rat hippocampus: role in adult neurogenesis.
|
14625142 |
2003 |
|
Dupuytren's Disease
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
WNT2 is a susceptibility locus for PD and our finding provides evidence for a partly shared genetic susceptibility between PD and DD.
|
22489561 |
2012 |
|
Dupuytren's Disease
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
Wnt signaling and Dupuytren's disease.
|
21732829 |
2011 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Gibbs sampling identified two disturbed pathways (pathways in cancer and influenza A) and two hub genes (cyclin A1 and WNT2) under the adjusted probability >0.8.
|
30867698 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FUND: This study was supported by the University of Luxembourg (IRP grant scheme; R-AGR-0755-12), the Luxembourg National Research Fund (FNR PRIDE PRIDE15/10675146/CANBIO), the Fondation Cancer (Luxembourg), the European Union's Horizon2020 research and innovation programme under the Marie Sklodowska- Curie grant agreement No 642295 (MEL-PLEX), and the German Federal Ministry of Education and Research (BMBF) within the project MelanomSensitivity (BMBF/BM/7643621).
|
31126892 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Wnt2 expression in CAFs was significantly correlated with depth of tumor (P < .001), lymph node metastasis (P = .044), TNM stage (P = .010), venous invasion (P < .001), and recurrence (P = .013).
|
31468733 |
2019 |
|
Waist-Hip Ratio
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
FUND: This study was supported by the University of Luxembourg (IRP grant scheme; R-AGR-0755-12), the Luxembourg National Research Fund (FNR PRIDE PRIDE15/10675146/CANBIO), the Fondation Cancer (Luxembourg), the European Union's Horizon2020 research and innovation programme under the Marie Sklodowska- Curie grant agreement No 642295 (MEL-PLEX), and the German Federal Ministry of Education and Research (BMBF) within the project MelanomSensitivity (BMBF/BM/7643621).
|
31126892 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Gibbs sampling identified two disturbed pathways (pathways in cancer and influenza A) and two hub genes (cyclin A1 and WNT2) under the adjusted probability >0.8.
|
30867698 |
2019 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, we suggest a possible interaction mode of Wnt2 with the Fzd7 cysteine-rich domain (CRD)-both of which are up-regulated in some types of cancer.
|
30191337 |
2018 |