WNT5A, Wnt family member 5A, 7474

N. diseases: 375; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE The performance of the proposed methodology is investigated by applying a state-feedback controller to two GRN models: a melanoma WNT5A Boolean network and a p53-MDM2 negative feedback loop Boolean network, when the cost of the undesirable states, and thus the identity of the undesirable genes, is learned using the proposed methodology. 29993697 2020
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE Taken together, these results indicate that Wnt5a activates the NF-κB pathway and has an immunomodulatory effect on melanoma through the secretion of cytokines and chemokines. 31510045 2019
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE Wnt5a has been implicated in melanoma progression and metastasis, although the exact downstream signaling events that contribute to melanoma metastasis are poorly understood. 29648538 2018
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE In melanoma, resistance to targeted therapy has been linked to expression of Wnt5A, an intrinsic inhibitor of β-catenin, which also promotes invasion. 28887323 2017
CUI: C0025202
Disease: melanoma
melanoma
0.100 GeneticVariation disease BEFREE Furthermore, the effectiveness of the proposed method is shown by a numerical example on a WNT5A network, which is related to melanoma. 26357060 2016
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE Overexpression of wingless-type MMTV integration site family 5A (WNT5A) plays a significant role in melanoma cancer progression; however, the mechanism(s) involved remains unknown. 26970271 2016
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE Furthermore, silencing of GLUT1 in the melanoma cells resulted in the increased expression of WNT5A and the decreased ability of invasion and proliferation in the melanoma cells. 26934938 2016
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE To understand how store-operated calcium entry (SOCE) contributes to Wnt5A-induced malignancy in melanoma models, we examined the expression and function of STIM1 and Orai1 in patient-derived malignant melanoma cells, previously characterized as either highly invasive (metastatic) or noninvasive. 26055321 2015
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE High expression of WNT5A in melanoma tumors correlates to formation of distant metastasis and poor prognosis. 24766647 2014
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE Furthermore, increased WNT5A expression in BRAFi-resistant melanomas correlates with a specific transcriptional signature, which identifies potential therapeutic targets to reduce clinical BRAFi resistance. 24865425 2014
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE Wnt5a has been shown to play an important role in EMT in prostate cancer and melanoma, but its role in colon cancer is still ambiguous. 24464650 2014
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE We have previously shown that Wnt5A-mediated signaling can promote melanoma metastasis. 20955350 2011
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE As ROR2 has been shown to specifically interact with the non-canonical Wnt ligand, Wnt5A, this corroborates our earlier data implicating Wnt5A as a mediator of melanoma metastasis. 19802008 2010
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration. 19470740 2009
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE Staining of a melanoma tissue array also highlighted the inverse relationship between MART-1 and Wnt5A expression. 19074888 2008
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease LHGDN Cytoplasmic WNT5A showed a trend of increasing expression with melanoma progression (P = 0.013), whereas there was diminishing p16(ink4a) expression (P = 0.006). 18794093 2008
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease LHGDN Staining of a melanoma tissue array also highlighted the inverse relationship between MART-1 and Wnt5A expression. 19074888 2008
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE The intervention procedure is applied to a WNT5A network to reduce the risk of metastasis in melanoma, and the identification procedure is applied to a Drosophila melanogaster segmentation polarity gene network to identify regulatory function perturbation. 17379691 2007
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease LHGDN Expression of Wnt5a, MMP7, and beta-catenin was determined in 40 primary uveal melanomas by immunohistochemistry and correlated with patient prognosis. 17992121 2007
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE Furthermore, inhibition of PKC before Wnt5A treatment blocked Snail expression, implying that Wnt5A can potentiate melanoma metastasis via the induction of EMT in a PKC-dependent manner. 17426020 2007
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE WNT5A is up-regulated in various types of human cancer, such as gastric cancer, lung cancer, and melanoma. 16273260 2005
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE Hierarchical clustering analysis of the expression data was able to distinguish between the melanoma and nonmelanoma samples and further stratified the melanoma samples into two groups differentiated by high expression of the genes involved in beta-catenin activation (EGFR and WNT5A) and the MAPK/ERK pathway (BRAF, FOS, and JUN). 16116595 2005
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE Furthermore, Wnt5a expression in human melanoma biopsies directly correlated to increasing tumor grade. 12086864 2002
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease LHGDN Furthermore, Wnt5a expression in human melanoma biopsies directly correlated to increasing tumor grade. 12086864 2002