|
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Wnt-11, a developmentally regulated gene producing a secreted protein, has been associated with various carcinomas but has not previously been studied in PDAC.
|
31718047 |
2019 |
|
Periapical Periodontitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here, we investigated the association of SNPs in/nearby WNT3, WNT3A, WNT5A, WNT8A, WNT9B and WNT11 genes with AP using a case-control dataset.
|
31831777 |
2019 |
|
Rectal Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Elevated Wnt-11 levels occurred more frequently in rectal tumors than in colonic tumors and in tumors from women than men.
|
31261741 |
2019 |
|
B-Cell Lymphomas
|
0.010 |
Biomarker
|
group |
BEFREE |
The experimental results indicated that upregulated miR-140 or silenced WNT11 increased cross-sectional areas of muscle fiber while decreasing lactic acid production, skeletal muscle cell apoptosis [corresponding to downregulated B cell lymphoma 2 (Bcl-2)-associated X protein (Bax) and caspase-3 and upregulated Bcl-2], and the proteolytic rate of Tyr and 3-MH.
|
31042421 |
2019 |
|
Malignant neoplasm of mouth
|
0.010 |
GeneticVariation
|
group |
BEFREE |
This case-control study evaluated the association of SNPs in IRF6 (rs642961), WNT3A (rs708111), GSK3β (rs9879992), 8q24 (rs987525) and WNT11 (rs1533767), representing regions consistently identified as of susceptibility for oral clefts, with oral cancer (oral squamous cell carcinoma) and breast cancer.
|
30579133 |
2019 |
|
Lip and Oral Cavity Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This case-control study evaluated the association of SNPs in IRF6 (rs642961), WNT3A (rs708111), GSK3β (rs9879992), 8q24 (rs987525) and WNT11 (rs1533767), representing regions consistently identified as of susceptibility for oral clefts, with oral cancer (oral squamous cell carcinoma) and breast cancer.
|
30579133 |
2019 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Consistently with the in vitro data, human biopsies of PDAC showed significantly higher Wnt-11 mRNA levels compared with matched adjacent tissues.
|
31718047 |
2019 |
|
POPLITEAL PTERYGIUM SYNDROME, LETHAL TYPE
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
In contrast, some fecal bacteria, expression of other genes (CHT, HB-EGF, OCT-1, SMRT-1, WNT11) in the bladder urothelium, and urinary DNA methylation in CpG-sites, MCP-3, G5P1, and HB-EGF were decreased in BPS.
|
31410520 |
2019 |
|
Degenerative polyarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Subsequently, using the quantitative RT-PCR analysis, we confirmed that in Wnt signaling pathway, the mRNA levels of Dickkopf WNT Signaling Pathway Inhibitor 2 (DKK2), Sex-determining Region Y-box 17 (SOX17), MYC, Cyclin D1, Calcium/Calmodulin Dependent Protein Kinase II Alpha (CAMK2A), and Wnt Family Member 11 and 5 were increased in facet joint osteoarthritis, while the mRNA levels of WNT Inhibitory Factor 1, Casein Kinase 1 Alpha 1, Transcription Factor 7/Lymphoid Enhancer Binding Factor 1 (TCF7/LEF1), and VANGL Planar Cell Polarity Protein 2 were decreased.
|
29806631 |
2018 |
|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study suggests that transplantation of MSCs genetically engineered with AAV-Akt1-Wnt11 is a promising therapeutic strategy for treatment of acute myocardial infarction.
|
30243083 |
2018 |
|
Interstitial Cystitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of WNT11 is associated with bladder tissue fibrosis in patients with interstitial cystitis/bladder pain syndrome without Hunner lesion.
|
29955137 |
2018 |
|
Chronic interstitial cystitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of WNT11 is associated with bladder tissue fibrosis in patients with interstitial cystitis/bladder pain syndrome without Hunner lesion.
|
29955137 |
2018 |
|
OVERLAP CONNECTIVE TISSUE DISEASE
|
0.010 |
Biomarker
|
disease |
BEFREE |
Wnt11 can regulate the development of the skeletal system and is related to high bone mass syndrome.
|
30010216 |
2018 |
|
Bladder pain syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of WNT11 is associated with bladder tissue fibrosis in patients with interstitial cystitis/bladder pain syndrome without Hunner lesion.
|
29955137 |
2018 |
|
Congenital Abnormality
|
0.010 |
Biomarker
|
group |
BEFREE |
Although the diverse cardiac malformations associated with the loss of non-canonical Wnt11 in mice such as outflow tract (OFT) defects, reduced ventricular trabeculation, myofibrillar disorganization and reduced cardiac marker gene expression are well described, the underlying molecular mechanisms are still not completely understood.
|
28237811 |
2017 |
|
Coronary heart disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Importantly, downregulation of Wnt11 expression was associated with cyanotic congenital heart defect (CHD) phenotypes and correlated with O2 saturation levels in hypoxemic infants with Tetralogy of Fallot (TOF).
|
28878122 |
2017 |
|
Congenital Heart Defects
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Importantly, downregulation of Wnt11 expression was associated with cyanotic congenital heart defect (CHD) phenotypes and correlated with O2 saturation levels in hypoxemic infants with Tetralogy of Fallot (TOF).
|
28878122 |
2017 |
|
Tetralogy of Fallot
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Finally, downregulated Wnt11 in hypoxemic TOF infantile hearts was associated with Rb1 suppression and induction of proliferation markers.
|
28878122 |
2017 |
|
Intervertebral Disc Degeneration
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Therefore, the Wnt11 overexpression may have a potential utility for the treatment of the intervertebral disc degeneration.
|
28429362 |
2017 |
|
Aortic valve calcification
|
0.010 |
Biomarker
|
disease |
BEFREE |
With accumulating evidence demonstrating that valve calcification recapitulates bone development, the crucial roles of noncanonical Wnt ligands WNT5a, WNT5b, and WNT11 in osteogenesis make them critical targets in the study of aortic valve calcification.
|
27932350 |
2017 |
|
Squamous cell carcinoma of the head and neck
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this work, we demonstrate for the first time that 1,8-cineol acts as an inhibitor of the Wnt/β-catenin activity in HNSCC <i>via</i> a decreased inhibition of GSK-3, which lead to reduced levels of WNT11 and a dose-dependent decrease of the cellular progression.
|
28589081 |
2017 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Piezo2 could regulate glioma angiogenesis via Ca2+/Wnt11/β-catenin signaling in endothelial cells.
|
27329839 |
2016 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Wnt11 Gene Therapy with Adeno-associated Virus 9 Improves Recovery from Myocardial Infarction by Modulating the Inflammatory Response.
|
26882996 |
2016 |
|
Human papilloma virus infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Wnt-11 and HR-HPV E6 expression increased in a manner that corresponded with the progression of cervical cancer and was significantly correlated with the International Federation of Gynecology and Obstetrics cancer stage, lymph node metastasis, tumor size, and HPV infection.
|
27034261 |
2016 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Wnt-11 and HR-HPV E6 expression increased in a manner that corresponded with the progression of cervical cancer and was significantly correlated with the International Federation of Gynecology and Obstetrics cancer stage, lymph node metastasis, tumor size, and HPV infection.
|
27034261 |
2016 |