|
Acute Cerebrovascular Accidents
|
0.300 |
Biomarker
|
disease |
CTD_human |
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
|
29531354 |
2018 |
|
Acute lymphocytic leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Reverse transcription polymerase chain reaction (RT-PCR) analysis of B-cell progenitor acute lymphoblastic leukaemia (ALL) cells revealed expression of Wnt genes, including WNT2B in 33%, WNT5A in 42%, WNT10B in 58% and WNT16B in 25% of cases.
|
17614820 |
2007 |
|
Allergic rhinitis (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
A total of 39 single nucleotide polymorphisms (SNPs) distributed over the genes PIP, WNT2B, CLC and PLUNC were selected from dbSNP, genotyped and investigated for associations with allergic rhinitis.
|
19650845 |
2010 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Twenty-four genes are significantly different from adult, and 13 genes might be developing hippocampus-specific candidate genes, including wnt2b and some Alzheimer's disease-related genes.
|
12271469 |
2002 |
|
Body Fat Distribution
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects.
|
30664634 |
2019 |
|
Brain Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The results showed that the expression of Wnt5a (41/45), Wnt10b (37/45), and Wnt13 (35/45) were found in brain tumors, whereas Wnt1 (6/45) was shown to be less related.
|
12049819 |
2002 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that the Wnt-13 gene may be involved in normal human development or differentiation as well as in human carcinogenesis.
|
8761309 |
1996 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data suggest that Wnt2B indeed plays an important role in ovarian cancer metastasis and drug resistance.
|
22635028 |
2012 |
|
Cardiovascular Diseases
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
CTD_human |
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
|
29531354 |
2018 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
GWASCAT |
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
|
29531354 |
2018 |
|
cervical cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Among various cancer cell lines, the Wnt-13 mRNA was detected in HeLa (cervical cancer), MKN28 and MKN74 (gastric cancer).
|
8761309 |
1996 |
|
Cervix carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Among various cancer cell lines, the Wnt-13 mRNA was detected in HeLa (cervical cancer), MKN28 and MKN74 (gastric cancer).
|
8761309 |
1996 |
|
Childhood Osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Up-regulated lnc-SNHG1 contributes to osteosarcoma progression through sequestration of miR-577 and activation of WNT2B/Wnt/β-catenin pathway.
|
29108989 |
2018 |
|
Chronic diarrhea
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Wnt2B co-operates with Frizzled7 to mediate MET in colorectal cancer.
|
28560804 |
2018 |
|
Congenital Abnormality
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Expression Analysis of ACSL5 and Wnt2B in Human Congenital Pulmonary Airway Malformations.
|
30463708 |
2018 |
|
Crohn Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, an increased co-localization of E-CADHERIN and VIMENTIN, an increased number of cells expressing WNT2b and a higher expression of FZD4 and WNT2b/FZD4 interaction were detected in intestinal tissue from the penetrating compared with the stenotic CD behavior.
|
31359032 |
2020 |
|
Cutaneous Melanoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
By performing functional prediction and stepwise selection, we identified two independent SNPs (i.e., WNT2B rs1175649 G>T and BTRC rs61873997 G>A) that showed a predictive role in CM-specific survival, with an effect-allele-attributed hazards ratio (adjusted hazards ratio) of 1.99 (95% confidence interval = 1.41-2.81, P = 8.10 × 10<sup>-5</sup>) and 0.61 (0.46-0.80, 3.12×10<sup>-4</sup>), respectively.
|
28499756 |
2017 |
|
Diarrhea
|
0.110 |
CausalMutation
|
phenotype |
CLINVAR |
|
|
|
|
Diarrhea
|
0.110 |
Biomarker
|
phenotype |
BEFREE |
WNT2B deficiency should be considered for individuals with neonatal-onset diarrhea.
|
29909964 |
2018 |
|
Diarrhea
|
0.110 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
DIARRHEA 9
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
|
Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
|
29455858 |
2018 |