WNT2B, Wnt family member 2B, 7482

N. diseases: 65; N. variants: 12
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011991
Disease: Diarrhea
Diarrhea 		0.110 Biomarker phenotype BEFREE WNT2B deficiency should be considered for individuals with neonatal-onset diarrhea. 29909964 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 AlteredExpression group BEFREE Strains KYC4030 and KYC4048 were determined to be <i>Myxococcus fulvus</i>, whereas strain KYC4081 was identified as <i>Corallococcus coralloides</i>.We found that metabolites of <i>M. fulvus</i> KYC4048 demonstrated no toxicity in normal cells but specifically induced cancer cell death by suppressing the expression of WNT2B. 29551019 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 AlteredExpression group BEFREE Here, we describe our investigations of expression of WNT2B mRNAs in various types of human primary cancer. 11741304 2001
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 AlteredExpression group BEFREE Differential regulation of WNT2 and WNT2B expression in human cancer. 11712082 2001
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 Biomarker group BEFREE Cancer gene therapy using an adenoviral vector expressing short hairpin RNA (shRNA) against Wnt2B was, therefore, found to have a strong antitumour effect against Wnt2B2-overexpressing tumours. 21646015 2012
CUI: C2931822
Disease: Nasopharyngeal carcinoma
Nasopharyngeal carcinoma 		0.040 Biomarker disease BEFREE The target gene of miR-185-3p, Wnt family member 2B (<i>WNT2B)</i> was silenced in 5-8F cells using siRNA in order to investigate its function in NPC. 28454443 2017
CUI: C2931822
Disease: Nasopharyngeal carcinoma
Nasopharyngeal carcinoma 		0.040 Biomarker disease BEFREE miR-324-3p suppresses migration and invasion by targeting WNT2B in nasopharyngeal carcinoma. 28053597 2017
CUI: C2931822
Disease: Nasopharyngeal carcinoma
Nasopharyngeal carcinoma 		0.040 Biomarker disease BEFREE Finally, the clinical significance of miRNA-324-3p and WNT2B was investigated in NPC tissues. 23583221 2013
CUI: C2931822
Disease: Nasopharyngeal carcinoma
Nasopharyngeal carcinoma 		0.040 AlteredExpression disease BEFREE We concluded that miR-185-3p contributed to the radioresistance of NPC via modulation of WNT2B expression in vitro. 25297925 2014
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.030 AlteredExpression group BEFREE Strains KYC4030 and KYC4048 were determined to be <i>Myxococcus fulvus</i>, whereas strain KYC4081 was identified as <i>Corallococcus coralloides</i>.We found that metabolites of <i>M. fulvus</i> KYC4048 demonstrated no toxicity in normal cells but specifically induced cancer cell death by suppressing the expression of WNT2B. 29551019 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.030 AlteredExpression group BEFREE Differential regulation of WNT2 and WNT2B expression in human cancer. 11712082 2001
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.030 Biomarker group BEFREE Cancer gene therapy using an adenoviral vector expressing short hairpin RNA (shRNA) against Wnt2B was, therefore, found to have a strong antitumour effect against Wnt2B2-overexpressing tumours. 21646015 2012
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.020 Biomarker phenotype BEFREE These data suggest that Wnt2B indeed plays an important role in ovarian cancer metastasis and drug resistance. 22635028 2012
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.020 Biomarker phenotype BEFREE The results of the present study indicate that miR-185-3p mediates the invasion and metastasis of NPC by targeting <i>WNT2B in vitro</i>. 28454443 2017
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome 		0.020 Biomarker disease BEFREE The role of MiR-324-3p in polycystic ovary syndrome (PCOS) via targeting WNT2B. 29917177 2018
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome 		0.020 Biomarker disease BEFREE Proliferation of Ovarian Granulosa Cells in Polycystic Ovarian Syndrome Is Regulated by MicroRNA-24 by Targeting Wingless-Type Family Member 2B (WNT2B). 31215527 2019
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 AlteredExpression phenotype BEFREE Wnt2B overexpression is thought to affect tumour progression through the activation of the canonical Wnt pathway. 21646015 2012
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 AlteredExpression phenotype BEFREE Wnt2B overexpression is thought to be involved in tumor progression through the activation of the canonical Wingless and INT-1 signaling pathway. 22635028 2012
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.020 Biomarker disease BEFREE These data suggest that Wnt2B indeed plays an important role in ovarian cancer metastasis and drug resistance. 22635028 2012
CUI: C0000768
Disease: Congenital Abnormality
Congenital Abnormality 		0.010 AlteredExpression group BEFREE Expression Analysis of ACSL5 and Wnt2B in Human Congenital Pulmonary Airway Malformations. 30463708 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.010 Biomarker disease BEFREE Twenty-four genes are significantly different from adult, and 13 genes might be developing hippocampus-specific candidate genes, including wnt2b and some Alzheimer's disease-related genes. 12271469 2002
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.010 Biomarker group BEFREE The results showed that the expression of Wnt5a (41/45), Wnt10b (37/45), and Wnt13 (35/45) were found in brain tumors, whereas Wnt1 (6/45) was shown to be less related. 12049819 2002
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.010 Biomarker disease BEFREE miR-577 suppresses cell proliferation and epithelial-mesenchymal transition by regulating the WNT2B mediated Wnt/β-catenin pathway in non-small cell lung cancer. 30015869 2018
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.010 AlteredExpression disease BEFREE Among various cancer cell lines, the Wnt-13 mRNA was detected in HeLa (cervical cancer), MKN28 and MKN74 (gastric cancer). 8761309 1996
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.010 AlteredExpression disease BEFREE Interestingly, both Wnt-13 and Notch transcripts are overexpressed in PBC liver. 11488641 2001