WNT2B, Wnt family member 2B, 7482

N. diseases: 65; N. variants: 12
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011991
Disease: Diarrhea
Diarrhea
0.110 CausalMutation phenotype CLINVAR
CUI: C0011991
Disease: Diarrhea
Diarrhea
0.110 Biomarker phenotype HPO
CUI: C0015544
Disease: Failure to Thrive
Failure to Thrive
0.100 Biomarker disease HPO
CUI: C0267456
Disease: Villous atrophy of intestine
Villous atrophy of intestine
0.100 Biomarker disease HPO
CUI: C0401151
Disease: Chronic diarrhea
Chronic diarrhea
0.100 CausalMutation disease CLINVAR
CUI: C0554101
Disease: Villous atrophy
Villous atrophy
0.100 Biomarker phenotype HPO
CUI: C1867873
Disease: Failure to thrive in infancy
Failure to thrive in infancy
0.100 CausalMutation phenotype CLINVAR
CUI: C2315100
Disease: Pediatric failure to thrive
Pediatric failure to thrive
0.100 CausalMutation disease CLINVAR
CUI: C4476942
Disease: Impaired feeding ability
Impaired feeding ability
0.100 CausalMutation phenotype CLINVAR
CUI: C4748517
Disease: DIARRHEA 9
DIARRHEA 9
0.100 CausalMutation disease CLINVAR
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.010 AlteredExpression disease BEFREE Among various cancer cell lines, the Wnt-13 mRNA was detected in HeLa (cervical cancer), MKN28 and MKN74 (gastric cancer). 8761309 1996
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.010 AlteredExpression disease BEFREE Among various cancer cell lines, the Wnt-13 mRNA was detected in HeLa (cervical cancer), MKN28 and MKN74 (gastric cancer). 8761309 1996
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.010 AlteredExpression disease BEFREE Among various cancer cell lines, the Wnt-13 mRNA was detected in HeLa (cervical cancer), MKN28 and MKN74 (gastric cancer). 8761309 1996
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.010 Biomarker phenotype BEFREE These results suggest that the Wnt-13 gene may be involved in normal human development or differentiation as well as in human carcinogenesis. 8761309 1996
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.010 AlteredExpression disease BEFREE Among various cancer cell lines, the Wnt-13 mRNA was detected in HeLa (cervical cancer), MKN28 and MKN74 (gastric cancer). 8761309 1996
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.010 AlteredExpression disease BEFREE Among various cancer cell lines, the Wnt-13 mRNA was detected in HeLa (cervical cancer), MKN28 and MKN74 (gastric cancer). 8761309 1996
CUI: C0206664
Disease: Teratocarcinoma
Teratocarcinoma
0.010 AlteredExpression disease BEFREE At least two members of the human frizzled gene family, thought to encode receptors for Wnt proteins, were also expressed in the NTERA-2 cells, suggesting the presence of a mechanism by which endogenously expressed Wnt-13 could modulate the histogenesis of teratocarcinomas by mediating interactions between sub-populations of differentiating EC cells. 9674702 1998
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.040 AlteredExpression group BEFREE Here, we describe our investigations of expression of WNT2B mRNAs in various types of human primary cancer. 11741304 2001
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.040 AlteredExpression group BEFREE Differential regulation of WNT2 and WNT2B expression in human cancer. 11712082 2001
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.030 AlteredExpression group BEFREE Differential regulation of WNT2 and WNT2B expression in human cancer. 11712082 2001
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis
0.010 AlteredExpression disease BEFREE Interestingly, both Wnt-13 and Notch transcripts are overexpressed in PBC liver. 11488641 2001
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.020 AlteredExpression disease LHGDN Wnt signaling in the ovary: identification and compartmentalized expression of wnt-2, wnt-2b, and frizzled-4 mRNAs. 12072409 2002
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.010 Biomarker disease BEFREE Twenty-four genes are significantly different from adult, and 13 genes might be developing hippocampus-specific candidate genes, including wnt2b and some Alzheimer's disease-related genes. 12271469 2002
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.010 Biomarker group BEFREE The results showed that the expression of Wnt5a (41/45), Wnt10b (37/45), and Wnt13 (35/45) were found in brain tumors, whereas Wnt1 (6/45) was shown to be less related. 12049819 2002
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms
0.010 Biomarker group LHGDN Anti-WNT2B monoclonal antibodies, WNT2B RNAi compounds, or small molecule WNT2B inhibitors could be developed as novel therapeutic agents for gastric cancer and esophageal cancer in the field of clinical oncology. 16273293 2005