|
Crohn Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, an increased co-localization of E-CADHERIN and VIMENTIN, an increased number of cells expressing WNT2b and a higher expression of FZD4 and WNT2b/FZD4 interaction were detected in intestinal tissue from the penetrating compared with the stenotic CD behavior.
|
31359032 |
2020 |
|
Congenital Abnormality
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Expression Analysis of ACSL5 and Wnt2B in Human Congenital Pulmonary Airway Malformations.
|
30463708 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
miR-577 suppresses cell proliferation and epithelial-mesenchymal transition by regulating the WNT2B mediated Wnt/β-catenin pathway in non-small cell lung cancer.
|
30015869 |
2018 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Wnt2B co-operates with Frizzled7 to mediate MET in colorectal cancer.
|
28560804 |
2018 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, based on data from the R2: Genomics Analysis and Visualization Platform, the expression of Wnt2b and 5a, and frizzled 2, 6 and 7 were highly associated with the prognosis of patients with glioma.
|
29387236 |
2018 |
|
Osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Up-regulated lnc-SNHG1 contributes to osteosarcoma progression through sequestration of miR-577 and activation of WNT2B/Wnt/β-catenin pathway.
|
29108989 |
2018 |
|
Osmotic diarrhea
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Homozygous nonsense mutations in WNT2B were identified in three individuals from two unrelated families with severe, neonatal-onset osmotic diarrhea after whole-exome sequencing was performed on trios from the two families.
|
29909964 |
2018 |
|
Osteosarcoma of bone
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Up-regulated lnc-SNHG1 contributes to osteosarcoma progression through sequestration of miR-577 and activation of WNT2B/Wnt/β-catenin pathway.
|
29108989 |
2018 |
|
Childhood Osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Up-regulated lnc-SNHG1 contributes to osteosarcoma progression through sequestration of miR-577 and activation of WNT2B/Wnt/β-catenin pathway.
|
29108989 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Wnt2B co-operates with Frizzled7 to mediate MET in colorectal cancer.
|
28560804 |
2018 |
|
Liver diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
These findings provided new insights into the pathophysiology of liver fibrosis by characterizing Wnt2b as a novel endogenous suppressor of TLR4 signaling, maintaining tissue homeostasis during the early stage of hepatic fibrosis-associated liver diseases.
|
28638086 |
2017 |
|
melanoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
By performing functional prediction and stepwise selection, we identified two independent SNPs (i.e., WNT2B rs1175649 G>T and BTRC rs61873997 G>A) that showed a predictive role in CM-specific survival, with an effect-allele-attributed hazards ratio (adjusted hazards ratio) of 1.99 (95% confidence interval = 1.41-2.81, P = 8.10 × 10<sup>-5</sup>) and 0.61 (0.46-0.80, 3.12×10<sup>-4</sup>), respectively.
|
28499756 |
2017 |
|
Cutaneous Melanoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
By performing functional prediction and stepwise selection, we identified two independent SNPs (i.e., WNT2B rs1175649 G>T and BTRC rs61873997 G>A) that showed a predictive role in CM-specific survival, with an effect-allele-attributed hazards ratio (adjusted hazards ratio) of 1.99 (95% confidence interval = 1.41-2.81, P = 8.10 × 10<sup>-5</sup>) and 0.61 (0.46-0.80, 3.12×10<sup>-4</sup>), respectively.
|
28499756 |
2017 |
|
Fibrosis, Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings provided new insights into the pathophysiology of liver fibrosis by characterizing Wnt2b as a novel endogenous suppressor of TLR4 signaling, maintaining tissue homeostasis during the early stage of hepatic fibrosis-associated liver diseases.
|
28638086 |
2017 |
|
Neural Tube Defects
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The results demonstrated that the transcriptional activities of Wnt2b and Wnt7b were abnormally upregulated in mouse fetuses with NTDs and, in the GC‑rich promoters of these genes, histone 3 lysine 4 (H3K4) acetylation was enriched, whereas H3K27 trimethylation was reduced.
|
26548512 |
2016 |
|
Myopia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The amounts of Wnt2b, Fzd5 and β-catenin mRNA and protein were significantly greater in form-deprived myopia eyes than in control eyes.DKK-1 (antagonist) reduced the myopic shift in refractive error and increase in axial elongation, whereas Norrin had the opposite effect in FDM eyes.
|
24755605 |
2014 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Using normal mucosa, the association of ACSL5 and Wnt2B was seen, but in intestinal neoplasias the mechanism was only rudimentarily observed.
|
25356045 |
2014 |
|
Refractive Errors
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The amounts of Wnt2b, Fzd5 and β-catenin mRNA and protein were significantly greater in form-deprived myopia eyes than in control eyes.DKK-1 (antagonist) reduced the myopic shift in refractive error and increase in axial elongation, whereas Norrin had the opposite effect in FDM eyes.
|
24755605 |
2014 |
|
Virus Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Here we show that secretion of WNT2B and WNT9B and stabilization of β-catenin (CTNNB1) upon virus infection negatively regulate expression of representative inducible genes IFNB1, IFIT1 and TNF in a CTNNB1-dependent effector mechanism.
|
23785285 |
2013 |
|
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data suggest that Wnt2B indeed plays an important role in ovarian cancer metastasis and drug resistance.
|
22635028 |
2012 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data suggest that Wnt2B indeed plays an important role in ovarian cancer metastasis and drug resistance.
|
22635028 |
2012 |
|
Allergic rhinitis (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
A total of 39 single nucleotide polymorphisms (SNPs) distributed over the genes PIP, WNT2B, CLC and PLUNC were selected from dbSNP, genotyped and investigated for associations with allergic rhinitis.
|
19650845 |
2010 |
|
Acute lymphocytic leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Reverse transcription polymerase chain reaction (RT-PCR) analysis of B-cell progenitor acute lymphoblastic leukaemia (ALL) cells revealed expression of Wnt genes, including WNT2B in 33%, WNT5A in 42%, WNT10B in 58% and WNT16B in 25% of cases.
|
17614820 |
2007 |
|
Esophageal Neoplasms
|
0.010 |
Biomarker
|
group |
LHGDN |
Anti-WNT2B monoclonal antibodies, WNT2B RNAi compounds, or small molecule WNT2B inhibitors could be developed as novel therapeutic agents for gastric cancer and esophageal cancer in the field of clinical oncology.
|
16273293 |
2005 |
|
Stomach Neoplasms
|
0.010 |
Biomarker
|
group |
LHGDN |
WNT2B: comparative integromics and clinical applications (Review).
|
16273293 |
2005 |