WNT2B, Wnt family member 2B, 7482

N. diseases: 65; N. variants: 12
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.100 GeneticVariation phenotype GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
CUI: C0428472
Disease: Serum HDL cholesterol measurement
Serum HDL cholesterol measurement 		0.100 GeneticVariation phenotype GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
CUI: C0015544
Disease: Failure to Thrive
Failure to Thrive 		0.100 Biomarker disease HPO
CUI: C0267456
Disease: Villous atrophy of intestine
Villous atrophy of intestine 		0.100 Biomarker disease HPO
CUI: C0401151
Disease: Chronic diarrhea
Chronic diarrhea 		0.100 CausalMutation disease CLINVAR
CUI: C0554101
Disease: Villous atrophy
Villous atrophy 		0.100 Biomarker phenotype HPO
CUI: C1867873
Disease: Failure to thrive in infancy
Failure to thrive in infancy 		0.100 CausalMutation phenotype CLINVAR
CUI: C2315100
Disease: Pediatric failure to thrive
Pediatric failure to thrive 		0.100 CausalMutation disease CLINVAR
CUI: C4476942
Disease: Impaired feeding ability
Impaired feeding ability 		0.100 CausalMutation phenotype CLINVAR
CUI: C4748517
Disease: DIARRHEA 9
DIARRHEA 9 		0.100 CausalMutation disease CLINVAR
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 AlteredExpression group BEFREE Strains KYC4030 and KYC4048 were determined to be <i>Myxococcus fulvus</i>, whereas strain KYC4081 was identified as <i>Corallococcus coralloides</i>.We found that metabolites of <i>M. fulvus</i> KYC4048 demonstrated no toxicity in normal cells but specifically induced cancer cell death by suppressing the expression of WNT2B. 29551019 2018
CUI: C2931822
Disease: Nasopharyngeal carcinoma
Nasopharyngeal carcinoma 		0.040 Biomarker disease BEFREE The target gene of miR-185-3p, Wnt family member 2B (<i>WNT2B)</i> was silenced in 5-8F cells using siRNA in order to investigate its function in NPC. 28454443 2017
CUI: C2931822
Disease: Nasopharyngeal carcinoma
Nasopharyngeal carcinoma 		0.040 Biomarker disease BEFREE miR-324-3p suppresses migration and invasion by targeting WNT2B in nasopharyngeal carcinoma. 28053597 2017
CUI: C2931822
Disease: Nasopharyngeal carcinoma
Nasopharyngeal carcinoma 		0.040 AlteredExpression disease BEFREE We concluded that miR-185-3p contributed to the radioresistance of NPC via modulation of WNT2B expression in vitro. 25297925 2014
CUI: C2931822
Disease: Nasopharyngeal carcinoma
Nasopharyngeal carcinoma 		0.040 Biomarker disease BEFREE Finally, the clinical significance of miRNA-324-3p and WNT2B was investigated in NPC tissues. 23583221 2013
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 Biomarker group BEFREE Cancer gene therapy using an adenoviral vector expressing short hairpin RNA (shRNA) against Wnt2B was, therefore, found to have a strong antitumour effect against Wnt2B2-overexpressing tumours. 21646015 2012
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 AlteredExpression group BEFREE Here, we describe our investigations of expression of WNT2B mRNAs in various types of human primary cancer. 11741304 2001
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 AlteredExpression group BEFREE Differential regulation of WNT2 and WNT2B expression in human cancer. 11712082 2001
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.030 AlteredExpression group BEFREE Strains KYC4030 and KYC4048 were determined to be <i>Myxococcus fulvus</i>, whereas strain KYC4081 was identified as <i>Corallococcus coralloides</i>.We found that metabolites of <i>M. fulvus</i> KYC4048 demonstrated no toxicity in normal cells but specifically induced cancer cell death by suppressing the expression of WNT2B. 29551019 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.030 Biomarker group BEFREE Cancer gene therapy using an adenoviral vector expressing short hairpin RNA (shRNA) against Wnt2B was, therefore, found to have a strong antitumour effect against Wnt2B2-overexpressing tumours. 21646015 2012
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.030 AlteredExpression group BEFREE Differential regulation of WNT2 and WNT2B expression in human cancer. 11712082 2001
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome 		0.020 Biomarker disease BEFREE Proliferation of Ovarian Granulosa Cells in Polycystic Ovarian Syndrome Is Regulated by MicroRNA-24 by Targeting Wingless-Type Family Member 2B (WNT2B). 31215527 2019
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome 		0.020 Biomarker disease BEFREE The role of MiR-324-3p in polycystic ovary syndrome (PCOS) via targeting WNT2B. 29917177 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.020 Biomarker phenotype BEFREE The results of the present study indicate that miR-185-3p mediates the invasion and metastasis of NPC by targeting <i>WNT2B in vitro</i>. 28454443 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.020 Biomarker phenotype BEFREE These data suggest that Wnt2B indeed plays an important role in ovarian cancer metastasis and drug resistance. 22635028 2012