WRN, WRN RecQ like helicase, 7486

N. diseases: 172; N. variants: 89
Disease: Werner Syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 Biomarker disease BEFREE WRN cell survival and the generation of viable mitotic recombinant progeny could be rescued by expressing wild-type WRN protein or by expressing the bacterial resolvase protein RusA. 12242278 2002
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 GeneticVariation disease BEFREE Werner's syndrome (WS) is a premature ageing disease caused by a mutation in the WRN gene. 16362795 2005
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 GeneticVariation disease BEFREE Werner syndrome and mutations of the WRN and LMNA genes in France. 16786514 2006
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 GeneticVariation disease BEFREE Werner syndrome (WS) is a rare human premature aging disease caused by mutations in the gene encoding the RecQ helicase WRN. 17284601 2007
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 Biomarker disease BEFREE Werner syndrome (WS) is a premature aging and cancer-prone disease caused by loss of the RecQ helicase WRN protein. 17624410 2007
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 GeneticVariation disease BEFREE Werner syndrome is an autosomal recessive disease of premature aging caused by a polymorphic C1367T mutation in the Werner (WRN) gene. 20808731 2010
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 GeneticVariation disease BEFREE Werner syndrome (WS) is an autosomal recessive progeroid disorder caused by mutations in the WRN DNA helicase. 22188495 2012
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 Biomarker disease BEFREE Werner syndrome (WS) is a disorder characterized by features of premature aging and increased cancer that is caused by loss of the RecQ helicase WRN. 22871734 2012
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 GeneticVariation disease BEFREE Werner syndrome is caused by mutations in the DNA repair Werner helicase (WRN) gene and characterized by accelerated aging including cataracts. 23334603 2013
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 GeneticVariation disease BEFREE Werner syndrome (WS) is a rare autosomal recessive disorder caused by mutations in the WRN gene. 23583337 2013
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 GeneticVariation disease BEFREE Werner syndrome is genetically linked to mutations in WRN that encodes a DNA helicase-nuclease believed to operate at stalled replication forks. 23867477 2013
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 GeneticVariation disease BEFREE Werner syndrome (WS) is a premature aging disorder caused by WRN protein deficiency. 25931448 2015
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 GeneticVariation disease BEFREE Werner syndrome (i.e., adult progeria) is a rare autosomal recessive disorder caused by mutations of the WRN gene, which is characterized by the premature appearance of features associated with normal aging and cancer predisposition. 27931782 2017
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 GeneticVariation disease BEFREE Werner syndrome (WS) is a progeroid-like syndrome caused by WRN gene mutations. 28158503 2017
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 GeneticVariation disease BEFREE Werner syndrome (WS) is a rare inheritable progeroid syndrome caused by a mutation in the WRN gene. 28738022 2017
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 GeneticVariation disease BEFREE Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases. 29146545 2018
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 GeneticVariation disease BEFREE Werner syndrome is a rare autosomal recessive disorder where Werner (WRN) gene is mutated. 31085421 2019
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 GeneticVariation disease BEFREE WRN is encoded by the gene that when mutated causes Werner's syndrome. 10540192 1999
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 Biomarker disease BEFREE WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts. 10811112 2000
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 Biomarker disease BEFREE WRN, the gene defective in WS, encodes a 1432 amino acid protein (hWRN) with intrinsic 3'-->5' DNA helicase activity. 10871373 2000
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 Biomarker disease BEFREE WRN and BLM genes causing WS and BS, encode proteins that are closely related to the RecQ helicase. 11840341 2002
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 Biomarker disease BEFREE WRN-1 is the Caenorhabditis elegans homolog of the human Werner syndrome protein, a RecQ helicase, mutations of which are associated with premature aging and increased genome instability. 20062519 2010
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 GeneticVariation disease BEFREE WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations. 20443122 2010
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 GeneticVariation disease BEFREE A 55-year-old patient with WS was studied and it was found that a deletion mutation of exon 26 of the WRN gene was not associated with CNS pathology, such as amyloid plaques or NFT. 12722926 2003
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 Biomarker disease BEFREE A Werner syndrome protein homolog in C. elegans (WRN-1) was immunolocalized to the nuclei of germ cells, embryonic cells, and many other cells of larval and adult worms. 15115755 2004