|
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, oncogenic potential of the WT1 gene has been proposed in some human solid tumors and leukemias.
|
17594113 |
2007 |
|
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutation analysis of the WT1 gene in sporadic childhood leukaemia.
|
9001425 |
1997 |
|
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The molecular basis of diseases such as Wilms tumor, WAGR, Denys-Drash or Frasier syndromes are congenital WT1 mutations, while somatic mutations of this gene occur in acute and chronic myeloid leukemia, myelodysplastic syndrome and also in some other blood neoplasms, as acute lymphoblood leukemia.
|
28791954 |
2017 |
|
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study.
|
18559874 |
2008 |
|
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Wilms tumour (WT1) gene is mutated in a secondary leukaemia in a WAGR patient.
|
7833922 |
1994 |
|
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To explore the possibility of gene therapy for leukemia using WT1 promoter and enhancer, their activities in several kinds of cells were analyzed by using the enhanced green fluorescent protein (EGFP) gene as a reporter.
|
14737070 |
2004 |
|
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using the anti-WT1 MoAb 6F-H2 in an immunofluorescence assay on single cell level, we found the translated WT1 protein only in nuclei of leukemia blast cells but not in nuclei of normal CD34+ hematopoietic progenitor cells.
|
7596170 |
1995 |
|
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This review examines evidence from preclinical experiments and initial clinical trials to critically assess both the potential and current limitations of adoptive transfer of donor T-cells sensitized to selected minor alloantigens of the host or to peptide epitopes of proteins, differentially expressed by clonogenic leukemia cells, such as the Wilms tumor protein, WT-1, as a strategy to treat or prevent recurrence of leukemia in the post-transplant period.
|
20537908 |
2010 |
|
leukemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
WT1 is a tumor-associated antigen in colon cancer that can be recognized by in vitro stimulated cytotoxic T cells.
|
14961577 |
2004 |
|
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, vaccination of C57BL/6 mice with Ad-tWT1 generated WT1-specific cell-mediated and humoral immune responses and conferred protection against challenge with the leukemia cell line, mWT1-C1498.
|
19351755 |
2009 |
|
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Subsequent research has shown that the WT1 gene in many other cases acts as an oncogene, most prominently in leukaemia and lung cancer (even though these cancer forms can emerge as a result of many other aetiological factors).
|
25189877 |
2015 |
|
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, we developed a WT1 oral cancer vaccine using a recombinant Bifidobacterium displaying WT1 protein, which can efficiently deliver WT1 protein to the gut immune system, and we demonstrated that this oral cancer vaccine had a significant anti-tumor effect in a C1498-WT1 murine leukemia syngeneic tumor model.
|
29048978 |
2018 |
|
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This finding suggests strongly that WT1 protein is a potential target of immunotherapy for human leukemia.
|
10607714 |
2000 |
|
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Due to its immunogenicity and overexpression concomitant with leukemia progression, Wilms tumor protein 1 (WT1) is of particular interest for immunotherapy of AML relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
|
27896368 |
2017 |
|
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, these results demonstrate that A1 is a new WT1 target gene involved in both granulocytic differentiation and resistance to cell death, and suggests that these genes might play an important role in the biology of high-risk leukemias.
|
16484585 |
2006 |
|
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Leukemias are common worldwide.Wilms' tumor1 (WT1) protein is highly expressed in leukemic blast cells of myeloid and lymphoid origin.
|
16491848 |
2006 |
|
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The usefulness of monitoring WT1 gene transcripts for the prediction and management of relapse following allogeneic stem cell transplantation in acute type leukemia.
|
12406915 |
2003 |
|
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results showed that Th1-biased humoral immune responses against WT1 protein were generated in leukemias and MDS.
|
15538407 |
2005 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Leukemic cells from seventy patients with various types of human leukemias were examined for expression of the WT1 gene, the Wilms' tumor gene located at chromosome 11p13.
|
1317488 |
1992 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Direct recognition and lysis of leukemia cells by WT1-specific CD4+ T lymphocytes in an HLA class II-restricted manner.
|
15845894 |
2005 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Multiplex real-time RT-PCR for prospective evaluation of WT1 and fusion gene transcripts in newly diagnosed de novo acute myeloid leukemia.
|
15223639 |
2004 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Minimal residual disease (MRD) of leukemia can be detected at frequencies as low as 1 in 10(3) to 10(4) normal bone marrow (BM) cells and 1 in 10(5) normal peripheral blood (PB) cells by means of the quantitation of expression levels of the WT1 gene using reverse transcriptase-polymerase chain reaction (RT-PCR).
|
9669676 |
1998 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Significant levels of WT1 gene were expressed in all leukemia patients and for CML the levels increased as the clinical phase progressed.
|
7949179 |
1994 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Wilms tumor 1 (WT1) oncoprotein is an intracellular oncogenic transcription factor which is barely expressed in normal adult tissues but over expressed in a variety of leukemias and solid cancers.
|
31408937 |
2019 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Wilms' tumor (WT1) protein is one of the potent tumor antigens inducing immunological response in mouse and human, because WT1 is over expressed in many types of leukemia and various kinds of solid tumors.
|
21963635 |
2011 |