leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Leukemic cells from seventy patients with various types of human leukemias were examined for expression of the WT1 gene, the Wilms' tumor gene located at chromosome 11p13.
|
1317488 |
1992 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using the anti-WT1 MoAb 6F-H2 in an immunofluorescence assay on single cell level, we found the translated WT1 protein only in nuclei of leukemia blast cells but not in nuclei of normal CD34+ hematopoietic progenitor cells.
|
7596170 |
1995 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, oncogenic potential of the WT1 gene has been proposed in some human solid tumors and leukemias.
|
17594113 |
2007 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutation analysis of the WT1 gene in sporadic childhood leukaemia.
|
9001425 |
1997 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Minimal residual disease (MRD) of leukemia can be detected at frequencies as low as 1 in 10(3) to 10(4) normal bone marrow (BM) cells and 1 in 10(5) normal peripheral blood (PB) cells by means of the quantitation of expression levels of the WT1 gene using reverse transcriptase-polymerase chain reaction (RT-PCR).
|
9669676 |
1998 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This review examines evidence from preclinical experiments and initial clinical trials to critically assess both the potential and current limitations of adoptive transfer of donor T-cells sensitized to selected minor alloantigens of the host or to peptide epitopes of proteins, differentially expressed by clonogenic leukemia cells, such as the Wilms tumor protein, WT-1, as a strategy to treat or prevent recurrence of leukemia in the post-transplant period.
|
20537908 |
2010 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Significant levels of WT1 gene were expressed in all leukemia patients and for CML the levels increased as the clinical phase progressed.
|
7949179 |
1994 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Wilms tumor 1 (WT1) oncoprotein is an intracellular oncogenic transcription factor which is barely expressed in normal adult tissues but over expressed in a variety of leukemias and solid cancers.
|
31408937 |
2019 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Wilms' tumor (WT1) protein is one of the potent tumor antigens inducing immunological response in mouse and human, because WT1 is over expressed in many types of leukemia and various kinds of solid tumors.
|
21963635 |
2011 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The Wilms tumor 1 (WT1) is an intracellular oncogenic transcription factor that is an attractive target for cancer immunotherapy because of its overexpression in a wide range of leukemias and solid tumors, and a low level of expression in normal adult tissues.
|
30045840 |
2018 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The molecular basis of diseases such as Wilms tumor, WAGR, Denys-Drash or Frasier syndromes are congenital WT1 mutations, while somatic mutations of this gene occur in acute and chronic myeloid leukemia, myelodysplastic syndrome and also in some other blood neoplasms, as acute lymphoblood leukemia.
|
28791954 |
2017 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The WT1 gene is highly expressed in leukemia and various types of solid tumors, whereas WT1 is a tumor marker convenient for the detection of minimal residual disease of leukemia.
|
20395243 |
2010 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, vaccination of C57BL/6 mice with Ad-tWT1 generated WT1-specific cell-mediated and humoral immune responses and conferred protection against challenge with the leukemia cell line, mWT1-C1498.
|
19351755 |
2009 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study.
|
18559874 |
2008 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In vitro IL-12 treatment of peripheral blood mononuclear cells from patients with leukemia or myelodysplastic syndromes: increase in cytotoxicity and reduction in WT1 gene expression.
|
10995011 |
2000 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The Wilms' tumour gene 1 (WT1) protein is highly expressed in most leukaemias.
|
17728783 |
2007 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Subsequent research has shown that the WT1 gene in many other cases acts as an oncogene, most prominently in leukaemia and lung cancer (even though these cancer forms can emerge as a result of many other aetiological factors).
|
25189877 |
2015 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Of these, 230 were monitored concurrently for minimal residual disease (MRD) by flow cytometry (FCM) for leukemia-associated aberrant immune phenotypes and by RQ-PCR for the expression of the Wilms tumor (WT1) gene.
|
24631740 |
2014 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, we developed a WT1 oral cancer vaccine using a recombinant Bifidobacterium displaying WT1 protein, which can efficiently deliver WT1 protein to the gut immune system, and we demonstrated that this oral cancer vaccine had a significant anti-tumor effect in a C1498-WT1 murine leukemia syngeneic tumor model.
|
29048978 |
2018 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Wilms tumor protein 1 (WT1) is a transcription factor overexpressed in several types of leukemia and solid tumors.
|
16990779 |
2006 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression of WT1 gene was measured according to the European Leukaemia Net recommendations.
|
23231003 |
2013 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The extent of minimal residual disease (MRD) of leukemia can be evaluated by measuring the WT1 gene expression level using a quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) method.
|
15223632 |
2004 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This finding suggests strongly that WT1 protein is a potential target of immunotherapy for human leukemia.
|
10607714 |
2000 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Wilms tumour (WT1) gene is mutated in a secondary leukaemia in a WAGR patient.
|
7833922 |
1994 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression of the WT-1 gene which is found exclusively in human leukemic blasts frequently disappears from bone marrow of leukemia patients in complete remission (CR).
|
9339129 |
1997 |