WT1, WT1 transcription factor, 7490

N. diseases: 446; N. variants: 61
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Leukemias are common worldwide.Wilms' tumor1 (WT1) protein is highly expressed in leukemic blast cells of myeloid and lymphoid origin. 16491848 2006
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Wilms tumor protein 1 (WT1) is a transcription factor overexpressed in several types of leukemia and solid tumors. 16990779 2006
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation disease BEFREE Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. 18559874 2008
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE WT1 gene expression has been proposed as a useful marker of minimal residual disease in leukaemia. 19650884 2009
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Wilms tumor 1 (WT1) oncoprotein is an intracellular oncogenic transcription factor which is barely expressed in normal adult tissues but over expressed in a variety of leukemias and solid cancers. 31408937 2019
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease LHGDN Direct recognition and lysis of leukemia cells by WT1-specific CD4+ T lymphocytes in an HLA class II-restricted manner. 15845894 2005
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Due to its immunogenicity and overexpression concomitant with leukemia progression, Wilms tumor protein 1 (WT1) is of particular interest for immunotherapy of AML relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT). 27896368 2017
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE However, the wild-type WT1 gene is highly expressed in leukemic blast cells of myeloid and lymphoid origin, and thus, WT1 messenger RNA provides a novel tumor marker for detection of minimal residual disease of leukemias and for monitoring disease progression of myelodysplastic syndromes. 11372729 2001
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE In addition, vaccination of C57BL/6 mice with Ad-tWT1 generated WT1-specific cell-mediated and humoral immune responses and conferred protection against challenge with the leukemia cell line, mWT1-C1498. 19351755 2009
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE In vitro IL-12 treatment of peripheral blood mononuclear cells from patients with leukemia or myelodysplastic syndromes: increase in cytotoxicity and reduction in WT1 gene expression. 10995011 2000
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Leukemic cells from seventy patients with various types of human leukemias were examined for expression of the WT1 gene, the Wilms' tumor gene located at chromosome 11p13. 1317488 1992
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Minimal residual disease (MRD) of leukemia can be detected at frequencies as low as 1 in 10(3) to 10(4) normal bone marrow (BM) cells and 1 in 10(5) normal peripheral blood (PB) cells by means of the quantitation of expression levels of the WT1 gene using reverse transcriptase-polymerase chain reaction (RT-PCR). 9669676 1998
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Most cases of leukemia show hTERT and WT1 gene overexpression. 21314483 2011
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease LHGDN Multiplex real-time RT-PCR for prospective evaluation of WT1 and fusion gene transcripts in newly diagnosed de novo acute myeloid leukemia. 15223639 2004
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation disease BEFREE Mutation analysis of the WT1 gene in sporadic childhood leukaemia. 9001425 1997
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Of these, 230 were monitored concurrently for minimal residual disease (MRD) by flow cytometry (FCM) for leukemia-associated aberrant immune phenotypes and by RQ-PCR for the expression of the Wilms tumor (WT1) gene. 24631740 2014
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease LHGDN Quantitative assessment of WT1 expression in diagnosis of childhood acute leukemia. 16876863 2007
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation disease BEFREE Recently, oncogenic potential of the WT1 gene has been proposed in some human solid tumors and leukemias. 17594113 2007
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Recently, we developed a WT1 oral cancer vaccine using a recombinant Bifidobacterium displaying WT1 protein, which can efficiently deliver WT1 protein to the gut immune system, and we demonstrated that this oral cancer vaccine had a significant anti-tumor effect in a C1498-WT1 murine leukemia syngeneic tumor model. 29048978 2018
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE Significant levels of WT1 gene were expressed in all leukemia patients and for CML the levels increased as the clinical phase progressed. 7949179 1994
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Subsequent research has shown that the WT1 gene in many other cases acts as an oncogene, most prominently in leukaemia and lung cancer (even though these cancer forms can emerge as a result of many other aetiological factors). 25189877 2015
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker disease BEFREE Taken together, these results demonstrate that A1 is a new WT1 target gene involved in both granulocytic differentiation and resistance to cell death, and suggests that these genes might play an important role in the biology of high-risk leukemias. 16484585 2006
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE The Wilms' tumor 1 (WT1) gene is overexpressed in leukemia and various types of solid tumor, such as lung and colorectal cancer, and plays an oncogenic role in their tumorigenesis. 20180815 2010
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE The WT1 gene is highly expressed in leukemia and various types of solid tumors, whereas WT1 is a tumor marker convenient for the detection of minimal residual disease of leukemia. 20395243 2010
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression disease BEFREE The Wilms tumor 1 (WT1) is an intracellular oncogenic transcription factor that is an attractive target for cancer immunotherapy because of its overexpression in a wide range of leukemias and solid tumors, and a low level of expression in normal adult tissues. 30045840 2018