|
leukemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
WT1 is a tumor-associated antigen in colon cancer that can be recognized by in vitro stimulated cytotoxic T cells.
|
14961577 |
2004 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Use of B cell-bound HLA-A2 class I monomers to generate high-avidity, allo-restricted CTLs against the leukemia-associated protein Wilms tumor antigen.
|
14988155 |
2004 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The extent of minimal residual disease (MRD) of leukemia can be evaluated by measuring the WT1 gene expression level using a quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) method.
|
15223632 |
2004 |
|
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To explore the possibility of gene therapy for leukemia using WT1 promoter and enhancer, their activities in several kinds of cells were analyzed by using the enhanced green fluorescent protein (EGFP) gene as a reporter.
|
14737070 |
2004 |
|
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The usefulness of monitoring WT1 gene transcripts for the prediction and management of relapse following allogeneic stem cell transplantation in acute type leukemia.
|
12406915 |
2003 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
However, the wild-type WT1 gene is highly expressed in leukemic blast cells of myeloid and lymphoid origin, and thus, WT1 messenger RNA provides a novel tumor marker for detection of minimal residual disease of leukemias and for monitoring disease progression of myelodysplastic syndromes.
|
11372729 |
2001 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In vitro IL-12 treatment of peripheral blood mononuclear cells from patients with leukemia or myelodysplastic syndromes: increase in cytotoxicity and reduction in WT1 gene expression.
|
10995011 |
2000 |
|
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This finding suggests strongly that WT1 protein is a potential target of immunotherapy for human leukemia.
|
10607714 |
2000 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Minimal residual disease (MRD) of leukemia can be detected at frequencies as low as 1 in 10(3) to 10(4) normal bone marrow (BM) cells and 1 in 10(5) normal peripheral blood (PB) cells by means of the quantitation of expression levels of the WT1 gene using reverse transcriptase-polymerase chain reaction (RT-PCR).
|
9669676 |
1998 |
|
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutation analysis of the WT1 gene in sporadic childhood leukaemia.
|
9001425 |
1997 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression of the WT-1 gene which is found exclusively in human leukemic blasts frequently disappears from bone marrow of leukemia patients in complete remission (CR).
|
9339129 |
1997 |
|
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using the anti-WT1 MoAb 6F-H2 in an immunofluorescence assay on single cell level, we found the translated WT1 protein only in nuclei of leukemia blast cells but not in nuclei of normal CD34+ hematopoietic progenitor cells.
|
7596170 |
1995 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Significant levels of WT1 gene were expressed in all leukemia patients and for CML the levels increased as the clinical phase progressed.
|
7949179 |
1994 |
|
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Wilms tumour (WT1) gene is mutated in a secondary leukaemia in a WAGR patient.
|
7833922 |
1994 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Leukemic cells from seventy patients with various types of human leukemias were examined for expression of the WT1 gene, the Wilms' tumor gene located at chromosome 11p13.
|
1317488 |
1992 |