Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A functional polymorphism (-116C-->G) in the XBP1 promoter was linked in some studies to bipolar disorder.
|
19154631 |
2009 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A possible association between the -116C/G single nucleotide polymorphism of the XBP1 gene and lithium prophylaxis in bipolar disorder.
|
15927087 |
2006 |
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
In a previous study, we suggested a possible link between XBP1 and bipolar disorder, but its role in neuronal cells has not yet been clarified.
|
16539657 |
2006 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In order to test this hypothesis, we investigated a functional polymorphism -197C/G in XBP1, which was reported to increase the risk of bipolar disorder, in a case-control study (374 cases vs. 371 controls) to evaluate its genetic role in the pathogenesis of schizophrenia.
|
15184063 |
2004 |
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Induction of the spliced form of XBP1 as well as total XBP1 by thapsigargin was significantly attenuated in patients with BD.
|
18771604 |
2009 |
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Induction of the spliced form of XBP1 as well as total XBP1 by thapsigargin was significantly attenuated in patients with BD.
|
18771604 |
2009 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Molecular genetics studies have already identified some candidate genes; for example, the BDNF, G72 and XBP1 genes, and chromosomal 'hot spots', which may confer a predisposition to development of bipolar disorder.
|
15948763 |
2005 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Preliminary evidence on the association between XBP1-116C/G polymorphism and response to prophylactic treatment with valproate in bipolar disorders.
|
19564049 |
2009 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, a polymorphism of XBP1, a pivotal gene in the endoplasmic reticulum (ER) stress response, was shown to contribute to the genetic risk factor for bipolar disorder.
|
16154272 |
2005 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, a polymorphism of the XBP1 gene (-116 C/G) was observed to play a significant role in the development of bipolar mood disorder from the Japanese population.
|
15892135 |
2005 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The XBP1-116C/G polymorphism is associated with an increased risk of bipolar disorder in Asian population.
|
25231123 |
2014 |
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The XBP1-116C/G polymorphism is associated with an increased risk of bipolar disorder in Asian population.
|
25231123 |
2014 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These negative findings suggest that the XBP1 C--116G polymorphism does not play a major role in the pathogenesis of bipolar disorders in Chinese populations.
|
15331160 |
2004 |
Bipolar Disorder
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
These results indicate that the -116C-->G polymorphism in XBP1 causes an impairment of its positive feedback system and increases the risk of bipolar disorder.
|
12949534 |
2003 |
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that the -116C-->G polymorphism in XBP1 causes an impairment of its positive feedback system and increases the risk of bipolar disorder.
|
12949534 |
2003 |
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Total XBP1 (F(1/126) = 9.550, p = 0.002, Partial η<sup>2</sup> = 0.070) and unspliced XBP1 (F(1/128)= 8.803, p= 0.004, Patial η<sup>2</sup> = 0.065) were significantly decreased in BD.
|
29843019 |
2018 |