XIST, X inactive specific transcript, 7503

N. diseases: 146; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.080 Biomarker disease BEFREE The present study suggested that lncRNA XIST acted as an oncogene in osteosarcoma, which may make it a novel therapeutic target for the treatment of osteosarcoma. 30655762 2019
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.080 Biomarker disease BEFREE Thus, XIST may be a potential therapeutic target for the treatment of OS. 30651857 2019
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.080 Biomarker disease BEFREE Our results showed that suppression of XIST by short hairpin RNA (shRNA) impeded U2OS cell growth, induced apoptosis and lessened OS xenograft tumor growth. 31189404 2019
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.080 Biomarker disease BEFREE We propose that XIST is responsible for OS cell proliferation and invasion and that XIST exerts its function through the miR-320b/RAP2B axis. 28409547 2018
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.080 AlteredExpression disease BEFREE Our results demonstrated that XIST expression was significantly upregulated in OS tissues and cell lines and negatively correlated with clinical prognosis. 29384226 2018
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.080 AlteredExpression disease BEFREE The results showed that XIST was significantly up-regulated in osteosarcoma tissues and cell lines, and high XIST expression was significantly associated with advanced tumor size (p=0.009), advanced clinical stage (p=0.001) and present distant metastasis (p=0.009). 28682435 2017
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.080 Biomarker disease BEFREE These results indicated that XIST functioned as a tumor suppressor in OS. 29048648 2017
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.080 Biomarker disease BEFREE RSF1 functions as an oncogene in osteosarcoma and is regulated by XIST/miR-193a-3p axis. 28843909 2017