Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE XRCC1 Arg399Gln and Arg194Trp polymorphisms in childhood acute lymphoblastic leukemia risk: a meta-analysis. 22712837 2013
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE XRCC1 194Trp allele was found to be associated with a low level of postrepair DNA damage in the ALL survivors. 24577548 2015
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE Accordingly, the co-presence of Tyr113His variant of EPHX1 and Arg399Gln variant of XRCC1 in the same individuals significantly increased the risk of childhood ALL up to 2.1-fold (OR = 2.1, P = 0.03). 21983886 2012
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease CTD_human Accordingly, the co-presence of Tyr113His variant of EPHX1 and Arg399Gln variant of XRCC1 in the same individuals significantly increased the risk of childhood ALL up to 2.1-fold (OR = 2.1, P = 0.03). 21983886 2012
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE In the scope of this study, we have also showed that the co-presence of XRCC1 codon 399 and CYP2E1*5B and *6 polymorphisms (data for CYP2E1 polymorphisms drawn from previously published study conducted in our lab) in the same individuals considerably increased the risk for childhood ALL to 3.7-fold with borderline significance (p=0.049). 20394984 2010
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE In this pilot study, through the use of PCR and RFLP, further confirmed by DNA sequencing, we have shown an increased risk of ALL among children with XRCC1 codons 194 and 399 variant genotypes. 15596292 2005
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE Significant association between XRCC1 Arg399Gln polymorphism and childhood ALL risk was observed in total population analyses (OR(additive model) = 1.501, 95% CI 1.112-2.026, P(OR) = 0.008; OR(dominant model) = 1.316, 95% CI = 1.104-1.569, P(OR) = 0.002) and Asian subgroup analyses (OR(additive model) = 2.338, 95%CI = 1.254-4.359, P(OR) = 0.008; OR(dominant model) = 2.108, 95%CI = 1.498-2.967, P(OR) = 0.000). 22529951 2012
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE The frequency of the XRCC1 haplotype B (194Trp-280Arg-399Arg) was significantly lower in children with ALL when compared to controls. 16435384 2007
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE This finding indicates that females carrying XRCC1 194Trp allele are at increased risk of developing childhood ALL. 19101034 2009
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE We examined the influence of the Arg194Trp, Arg280His, and Arg399Gln polymorphisms of XRCC1 (X-ray repair cross-complementing group 1) on the development of childhood acute lymphoblastic leukemia (ALL) in 120 ALL patients and 120 controls in Mexico. 20013659 2009
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE We found that the combined genotype Arg/Gln-Cys/Cys of XRCC1/OGG1 (OR 3.83) as well as the Cys/Cys-Tyr/Tyr of OGG1/MUTYH (OR 6.75) increases the risk of ALL. 20364408 2011