Absence of sensation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In conclusion, this study showed modulations of hOGG1 and XRCC1 expression especially 1 day after elective surgery in patients undergoing PROP and ISO anaesthesia.
|
29669111 |
2018 |
Absent reflex
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Acquired cystic disease associated renal cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
ACKD-RCC-like cysts should be recognized as a distinct entity from ACKD-RCC, defined by the lack of any solid nodular growth within the cyst.
|
30001236 |
2018 |
Acute dermatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our investigation shows, for the first time, that patients with the XRCC1 399Arg/Gln genotype were more likely to experience severe acute dermatitis and oral mucositis.
|
23375119 |
2013 |
Acute leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest a possible association between electric transformers and power lines and the XRCC1 Ex9+16A allele in patients with childhood AL.
|
19052983 |
2008 |
Acute lymphocytic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
XRCC1 polymorphisms and haplotypes in Mexican patients with acute lymphoblastic leukemia.
|
20013659 |
2009 |
Acute Promyelocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
They are structurally organized, containing canonical promyelocytic leukemia (PML) nuclear body protein SP100 concentrated in a peripheral layer, and XRCC1 in the center.
|
30260704 |
2019 |
Adenocarcinoma
|
0.080 |
GeneticVariation
|
group |
BEFREE |
XRCC1 Arg399Gln showed a borderline significant association with adenocarcinoma (adjusted OR 1.89, 95%CI 1.00-3.57, p=0.051).
|
21198260 |
2010 |
Adenocarcinoma
|
0.080 |
GeneticVariation
|
group |
BEFREE |
In the subgroup of adenocarcinoma cases, adjusted ORs were increased for individuals with homozygous XRCC1 399Gln/Gln genotype (OR=2.62, 95% CI [1.44-4.79]) and XRCC1 -77 combined TC and CC genotype (OR=1.85, 95% CI [1.19-2.86]).
|
18407370 |
2008 |
Adenocarcinoma
|
0.080 |
GeneticVariation
|
group |
BEFREE |
The associations between the OGG1 Cys/Cys genotype and adenocarcinoma risk and between XRCC1 Arg194Trp polymorphism and lung cancer risk among heavy smokers remained robust given prior probabilities of 25% (FPRP = 0.238) and 10% (FPRP = 0.276), respectively.
|
15840879 |
2005 |
Adenocarcinoma
|
0.080 |
GeneticVariation
|
group |
LHGDN |
XRCC1 and XPD polymorphisms and esophageal adenocarcinoma risk.
|
17264068 |
2007 |
Adenocarcinoma
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms of XRCC1 gene and risk of gastric cardiac adenocarcinoma.
|
19673050 |
2009 |
Adenocarcinoma
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Furthermore, the greater risk for the double variant of p53 and XRCC1 in the SOD2 Val/Val genotype group was specific only for patients with adenocarcinoma and not for patients with squamous cell carcinoma, with adjusted ORs of 3.31 (95% CI, 1.68-6.51) and 0.69 (95% CI, 0.24-2.02), respectively.
|
15534883 |
2004 |
Adenocarcinoma
|
0.080 |
GeneticVariation
|
group |
BEFREE |
This is the first report that the XRCC1 Arg399Gln polymorphism might be important in relation to the risk of adenocarcinoma/adenosquamous carcinoma of the cervix.
|
15990162 |
2005 |
Adenocarcinoma
|
0.080 |
GeneticVariation
|
group |
LHGDN |
Association of single nucleotide polymorphisms in SOD2, XRCC1 and XRCC3 with susceptibility for the development of adverse effects resulting from radiotherapy for prostate cancer.
|
18582155 |
2008 |
Adenocarcinoma Of Esophagus
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Although no significant relationships were found for the XRCC1 Arg399Gln polymorphism alone, this polymorphism did modify the relationship between XPD Lys751Gln and EA risk; when both polymorphisms were evaluated together, adding the number of variant alleles of the two polymorphisms resulted in a significant trend (trend test, P = 0.008); compared with individuals with no variant alleles (n = 88), the adjusted ORs of developing EA are 1.49 (95% CI: 0.88-2.59), 1.69 (95% CI: 0.98-2.96) and 2.58 (95% CI: 1.31-5.06) for one (n = 195), two (n = 166) and three or four variant alleles (n = 70), respectively.
|
17264068 |
2007 |
Adenocarcinoma Of Esophagus
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
In a nationwide population-based case-control study, we examined associations of polymorphisms in the DNA repair genes XPD, XPC, XRCC1 and XRCC3 with risk of esophageal adenocarcinoma, squamous-cell carcinoma (SCC) and gastric cardia adenocarcinoma, and paid special attention to possible interactions with symptomatic reflux or body mass.
|
16571649 |
2006 |
Adenocarcinoma Of Esophagus
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The protective effect of the homozygous variant of XRCC1 Arg399Gln for GERD and BE suggests that base excision repair alterations may occur early in progression to EADC, likely in response to GERD-induced endogenous oxidative or inflammatory DNA damage.
|
15878910 |
2005 |
Adenocarcinoma of lung (disorder)
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
XRCC1 genotypes were assessed at codon 399 in 172 cases of lung adenocarcinoma and 143 cancer-free controls.
|
11104903 |
2001 |
Adenocarcinoma of lung (disorder)
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Increasing numbers of either ERCC1 118 or XRCC1 399 variant alleles were associated with shorter survival of non-smoking female lung adenocarcinoma patients (Log-rank P < 0.001).
|
20003463 |
2009 |
Adenocarcinoma of lung (disorder)
|
0.040 |
Biomarker
|
disease |
BEFREE |
Analysis of the presence of XRCC1 194Trp homozygote, POLdelta1 119His homozygote, and RAD9 239Arg heterozygote variants revealed that their coassociation leads to a significant risk for the development of lung adenocarcinoma.
|
20052722 |
2010 |
Adenocarcinoma of lung (disorder)
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Thus, this study reveals that a three-order interaction among the polymorphic sites of XPD-751, XRCC1-399, and OGG1-326 is associated with lung ADC risk in the studied population, although polymorphism in individual gene was not associated.
|
23700156 |
2013 |
Adenocarcinoma of pancreas
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma.
|
12183419 |
2002 |
Adenocarcinoma of prostate
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that SNPs in the SOD2, XRCC1 and XRCC3 genes are associated with the development of late radiation injury in patients treated with radiation therapy for prostate adenocarcinoma.
|
18582155 |
2008 |
Adenoma
|
0.030 |
GeneticVariation
|
group |
BEFREE |
High omega-6/omega-3 polyunsaturated fatty acid ratios were associated with adenoma risk among subjects with the XRCC1 codon 194 Arg/Arg and codon 399 Gln/Gln or the codon 194 Arg/Trp or Trp/Trp and codon 399 Arg/Arg or Arg/Gln combined genotypes (P for interaction = 0.026).
|
15767338 |
2005 |