XRCC1, X-ray repair cross complementing 1, 7515

N. diseases: 410; N. variants: 39
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE We found no evidence of an association between XRCC1 genotypes and glioma. 17898525 2007
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE However, in pair-wise comparisons a few SNP combinations were associated with the risk of brain tumors: Among others, carriers of both homozygous variant genotypes, i.e., XRCC1 Gln399Gln and XRCC3 Met241Met, were associated with a three-fold increased risk of glioma (OR = 3.18; 95% CI, 1.26-8.04) and meningioma (OR = 2.99; 95% CI, 1.16-7.72). 18330515 2008
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease LHGDN In the single-locus analysis, six single-nucleotide polymorphisms [ERCC1 3' untranslated region (UTR), XRCC1 R399Q, APEX1 E148D, PARP1 A762V, MGMT F84L, and LIG1 5'UTR] showed a significant association with glioma risk. 19124499 2009
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE The combined genotypes of XRCC1 AG or GG with PARP1 VA or AA, and XRCC1 AG or GG with PARP1 VV were more represented in the glioma patients (p = 0.001 and 0.003, respectively). 20868244 2010
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE Decreased glioma risk was observed with the XRCC1 rs1799782 variant (P(trend) .04). 20150366 2010
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE The XRCC1 Arg399Gln polymorphism may be a useful susceptibility biomarker for glioma. 22320953 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE Our study aimed to investigate any association between three polymorphisms of the XRCC1 gene at codon 194, 280 and 399 and potential glioma risk. 22393975 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE These results suggest that the XRCC1 Arg399Gln might influence the risk of developing glioma in a Han population in northeastern Chinese. 22951806 2012
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE A total of 11 studies (3,810 cases and 6,079 controls), 7 studies (2,928 cases and 5,048 controls), and 4 studies (1,461 cases and 2,593 controls) were finally included in the analyses of the association between XRCC1 Arg399Gln, Arg194Trp, and Arg280His polymorphisms and glioma risk, respectively. 23167420 2012
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE Our comprehensive analysis of nine SNPs in eight genes suggests that the rs730437 and rs1468727 in ERGF, rs1799782 in XRCC1 gene, and rs861539 in XRCC3 gene are associated with glioma risk. 23244079 2012
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE This meta-analysis does not suggest a major role of the XRCC1 399 G → A polymorphism in influencing risk of glioma among Caucasians. 23101479 2012
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE These preliminary findings indicate that the c.1471G>A genetic polymorphism of XRCC1 has the potential to influence glioma susceptibility, and might be used as molecular marker for assessing glioma risk. 24289608 2013
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE Odds ratios as well as their 95 % confidence intervals in three genetic models were used to estimate the strength of the association between XRCC1 genotypes and glioma risk. 23712607 2013
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE This meta-analysis was performed to derive a more precise estimation between XRCC1 polymorphisms (Arg399Gln, Arg194Trp, and Arg280His) and glioma risk. 23383237 2013
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE In conclusion, the results suggest that the XRCC 1 Arg399Gln polymorphism may contribute to the susceptibility of glioma in Asians. 23096083 2013
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE This study provides evidence that DNA repair genes ERCC1, ERCC2, and XRCC1 might be low-penetrance glioma-risk genes, while MGMT and PARP1 polymorphisms may confer protection against glioma. 24500421 2014
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE To further evaluate gene-gene and gene-environment interactions on XRCC1 polymorphisms and glioma risk, thousands of subjects and tissue-specific biochemical characterizations are required. 25227852 2014
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE Nevertheless, large-scale, well-designed and population-based studies are needed to further evaluate gene-gene and gene-environment interactions, as well as to measure the combined effects of these XRCC1 variants on glioma risk. 25375625 2014
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE Yet, it is necessary to conduct future prospective explorations to gain a better insight into the impact of XRCC1 Arg399Gln polymorphism on glioma risk. 24258108 2014
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease CTD_human To further evaluate gene-gene and gene-environment interactions on XRCC1 polymorphisms and glioma risk, thousands of subjects and tissue-specific biochemical characterizations are required. 25227852 2014
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE This study aimed to evaluate the potential association between XRCC1 genetic polymorphisms and glioma susceptibility. 23918303 2014
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE When stratified by the grade of glioma, patients with WHO IV glioma had a significantly higher frequency of XRCC1 194 TT (OR = 1.60, 95 % CI = 1.02, 2.51; P = 0.04) and XRCC1 399 AA genotype (OR = 1.59, 95 % CI = 1.04, 2.42; P = 0.03). 24048757 2014
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE This study demonstrates that the rs25489 (Arg280His) and Arg399Gln (rs25487) polymorphisms in XRCC1 gene might influence the risk of developing glioma in Chinese population. 25245010 2014
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE Our findings suggest that these genetic polymorphisms of XRCC1 gene may influence glioma risks in Chinese Han ethnic subjects, and might be potential molecular markers for evaluating glioma risks. 24375631 2014
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE In summary, we suggest that the XRCC1 Arg194Trp genetic polymorphism could be a predictive biomarker for the susceptibility to glioma in a Chinese population. 27706616 2016