Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
XRCC1 194Trp/Trp was strongly significantly associated with an increased risk of HCC cancer when compared with the wide-type genotype (OR=2.26, 95% CI=(1.23-5.38).
|
23167354 |
2012 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among participants who had all three suspected aflatoxin-related high-risk genotypes [GSTM1 null, HLY1*2 (HY/HH), and XRCC1 (AG/GG)], a significant 15-fold increased risk of HCC was observed albeit with imprecise estimates (OR, 14.7; 95% CI, 1.27-169).
|
15734960 |
2005 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Evaluation of DNA repair gene XRCC1 polymorphism in prediction and prognosis of hepatocellular carcinoma risk.
|
22502666 |
2012 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Five hundred one HCCs were included in this study to investigate the role of the XRCC1 codon 399 polymorphism on hotspot mutation in codon 249 of the p53 gene.
|
17849423 |
2008 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For XRCC1 Arg280His polymorphism, the overall analysis revealed the significant association between the His/His genotype and the increased risk of HCC (His/His vs Arg/Arg model, OR: 1.96, 95% CI: 1.03-3.75, P = 0.04).
|
22919255 |
2012 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, XRCC1 Arg399Gln polymorphism might act as a protective role against HCC among Caucasians.
|
24815482 |
2014 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, no report correlates the risk of HCC development with mEPHX and XRCC1 haplotypes.
|
19754350 |
2009 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, no potential contribution of XRCC1 Arg399Gln polymorphism to HCC susceptibility in HBV/HCV subgroups was identified.
|
24289575 |
2013 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, the data also showed that XRCC1 280His polymorphism was associated with HBV infection and HCC family history to increase HCC risk.
|
22565339 |
2012 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the Chinese Han population, the XRCC1 Arg399Gln gene polymorphism is associated with an increased hepatocellular carcinoma risk.
|
23098440 |
2012 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, the authors performed a meta-analysis to assess the association between XRCC1 Arg280His and HCC susceptibility.
|
23679314 |
2013 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis was used to analyze the association between single nucleotide polymorphisms of XRCC1 and XPD genes and the prognosis of patients with HCC.
|
28927037 |
2017 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
On the contrary, no relationship was observed between UGT1A7 polymorphisms considered alone or in interaction with GSTM1 or XRCC1 polymorphisms and HCC.
|
17870518 |
2007 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
On the other hand, a wild-type hOGG1 and XRCC1 combination was associated with a significantly higher risk of AVH (p=0.010) but a lower risk of CHBV (p=0.032) and HCC (p=0.006).
|
23454624 |
2013 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
On univariate analysis, a statistically significant association was found between risk of HCC and XRCC1 399Arg/Gln genotype (odd ratio [OR] = 1.88; 95% CI, 1.04-3.43), which was confirmed after adjusting by sex (OR = 1.94; 95% CI, 1.04-3.63).
|
28058700 |
2017 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our analysis provides evidence that the XRCC1 Arg399Gln polymorphism may be associated with a higher risk of HCC, especially among Asian populations.
|
24390232 |
2014 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our analysis suggests that the XRCC1 Arg280His polymorphism is associated with a higher risk of HCC.
|
26125922 |
2015 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings indicate that the studied XRCC1 genetic polymorphisms may influence the risk of HCC in Chinese populations and might be used as molecular markers for assessing the risk of HCC.
|
24570146 |
2014 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings support that c.1804C>A genetic polymorphism of XRCC1 gene plays a genetic influence on the susceptibility to HCC in the studied population.
|
24526467 |
2014 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis of the available data did not find an obvious effect of XRCC1 Arg399Gln polymorphism on hepatitis-related hepatocellular carcinoma.
|
23780894 |
2013 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that the XRCC1 Arg194Trp polymorphism could be a risk factor for HCV-related HCC development in Egypt.
|
29935355 |
2018 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study indicated that the XRCC1 rs25487 was a risk factor for the susceptibility of HCC, which was verified by the TSA.
|
31478224 |
2020 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism of DNA repair gene XRCC1 and hepatocellular carcinoma risk in Chinese population.
|
22393969 |
2011 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Results from this study indicate that the XRCC1 c.1471G>A polymorphism is associated with HCC susceptibility in the Chinese Han population.
|
24446299 |
2014 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Similarly, a significant association between XRCC1 Arg399Gln and HCC risk was found in healthy controls in the general population but not in hospital controls.
|
30408066 |
2018 |