XRCC1, X-ray repair cross complementing 1, 7515

N. diseases: 410; N. variants: 39
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE Decreased glioma risk was observed with the XRCC1 rs1799782 variant (P(trend) .04). 20150366 2010
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease LHGDN In the single-locus analysis, six single-nucleotide polymorphisms [ERCC1 3' untranslated region (UTR), XRCC1 R399Q, APEX1 E148D, PARP1 A762V, MGMT F84L, and LIG1 5'UTR] showed a significant association with glioma risk. 19124499 2009
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE However, in pair-wise comparisons a few SNP combinations were associated with the risk of brain tumors: Among others, carriers of both homozygous variant genotypes, i.e., XRCC1 Gln399Gln and XRCC3 Met241Met, were associated with a three-fold increased risk of glioma (OR = 3.18; 95% CI, 1.26-8.04) and meningioma (OR = 2.99; 95% CI, 1.16-7.72). 18330515 2008
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE We found no evidence of an association between XRCC1 genotypes and glioma. 17898525 2007