Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The combined genotypes of XRCC1 AG or GG with PARP1 VA or AA, and XRCC1 AG or GG with PARP1 VV were more represented in the glioma patients (p = 0.001 and 0.003, respectively).
|
20868244 |
2010 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Yet, it is necessary to conduct future prospective explorations to gain a better insight into the impact of XRCC1 Arg399Gln polymorphism on glioma risk.
|
24258108 |
2014 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests that glioma susceptibility is associated with rs1799782 and rs25487 of X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), rs1805377 of XRCC4, rs1800067 of excision repair cross-complementing rodent repair deficiency complementation group 4 (ERCC4) and rs3212986 of ERCC1 in Asian population, and rs12917 of O-6-methylguanine-DNA methyltransferase (MGMT) and rs1136410 of poly(ADP-ribose) polymerase 1 (PARP1) in Caucasian population.
|
27055523 |
2017 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Odds ratios as well as their 95 % confidence intervals in three genetic models were used to estimate the strength of the association between XRCC1 genotypes and glioma risk.
|
23712607 |
2013 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Decreased glioma risk was observed with the XRCC1 rs1799782 variant (P(trend) .04).
|
20150366 |
2010 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A total of 11 studies (3,810 cases and 6,079 controls), 7 studies (2,928 cases and 5,048 controls), and 4 studies (1,461 cases and 2,593 controls) were finally included in the analyses of the association between XRCC1 Arg399Gln, Arg194Trp, and Arg280His polymorphisms and glioma risk, respectively.
|
23167420 |
2012 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to evaluate the potential association between XRCC1 genetic polymorphisms and glioma susceptibility.
|
23918303 |
2014 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found no evidence of an association between XRCC1 genotypes and glioma.
|
17898525 |
2007 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, in pair-wise comparisons a few SNP combinations were associated with the risk of brain tumors: Among others, carriers of both homozygous variant genotypes, i.e., XRCC1 Gln399Gln and XRCC3 Met241Met, were associated with a three-fold increased risk of glioma (OR = 3.18; 95% CI, 1.26-8.04) and meningioma (OR = 2.99; 95% CI, 1.16-7.72).
|
18330515 |
2008 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In summary, we suggest that the XRCC1 Arg194Trp genetic polymorphism could be a predictive biomarker for the susceptibility to glioma in a Chinese population.
|
27706616 |
2016 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
When stratified by the grade of glioma, patients with WHO IV glioma had a significantly higher frequency of XRCC1 194 TT (OR = 1.60, 95 % CI = 1.02, 2.51; P = 0.04) and XRCC1 399 AA genotype (OR = 1.59, 95 % CI = 1.04, 2.42; P = 0.03).
|
24048757 |
2014 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our comprehensive analysis of nine SNPs in eight genes suggests that the rs730437 and rs1468727 in ERGF, rs1799782 in XRCC1 gene, and rs861539 in XRCC3 gene are associated with glioma risk.
|
23244079 |
2012 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrates that the rs25489 (Arg280His) and Arg399Gln (rs25487) polymorphisms in XRCC1 gene might influence the risk of developing glioma in Chinese population.
|
25245010 |
2014 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study aimed to investigate any association between three polymorphisms of the XRCC1 gene at codon 194, 280 and 399 and potential glioma risk.
|
22393975 |
2011 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis was performed to derive a more precise estimation between XRCC1 polymorphisms (Arg399Gln, Arg194Trp, and Arg280His) and glioma risk.
|
23383237 |
2013 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis does not suggest a major role of the XRCC1 399 G → A polymorphism in influencing risk of glioma among Caucasians.
|
23101479 |
2012 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the results suggest that the XRCC 1 Arg399Gln polymorphism may contribute to the susceptibility of glioma in Asians.
|
23096083 |
2013 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that these genetic polymorphisms of XRCC1 gene may influence glioma risks in Chinese Han ethnic subjects, and might be potential molecular markers for evaluating glioma risks.
|
24375631 |
2014 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Current evidence indicated that XRCC1 Arg194Trp polymorphism was associated with increased risk for glioma, especially in Asians; however, relevant studies involving other ethnic groups are required to validate our findings in further.
|
28423490 |
2017 |
Childhood Acute Lymphoblastic Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This finding indicates that females carrying XRCC1 194Trp allele are at increased risk of developing childhood ALL.
|
19101034 |
2009 |
Childhood Acute Lymphoblastic Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this pilot study, through the use of PCR and RFLP, further confirmed by DNA sequencing, we have shown an increased risk of ALL among children with XRCC1 codons 194 and 399 variant genotypes.
|
15596292 |
2005 |
Childhood Acute Lymphoblastic Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found that the combined genotype Arg/Gln-Cys/Cys of XRCC1/OGG1 (OR 3.83) as well as the Cys/Cys-Tyr/Tyr of OGG1/MUTYH (OR 6.75) increases the risk of ALL.
|
20364408 |
2011 |
Childhood Acute Lymphoblastic Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The frequency of the XRCC1 haplotype B (194Trp-280Arg-399Arg) was significantly lower in children with ALL when compared to controls.
|
16435384 |
2007 |
Childhood Acute Lymphoblastic Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We examined the influence of the Arg194Trp, Arg280His, and Arg399Gln polymorphisms of XRCC1 (X-ray repair cross-complementing group 1) on the development of childhood acute lymphoblastic leukemia (ALL) in 120 ALL patients and 120 controls in Mexico.
|
20013659 |
2009 |
Childhood Acute Lymphoblastic Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
XRCC1 Arg399Gln and Arg194Trp polymorphisms in childhood acute lymphoblastic leukemia risk: a meta-analysis.
|
22712837 |
2013 |