Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Moreover, in the subgroup analysis by cancer type, we found that XRCC1-rs25489 polymorphism was associated with an increased risk of bladder cancer (BC) in heterozygote model.
|
28330811 |
2017 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
APEX1 rs3136817, MUTYH rs3219493, three SNPs (rs3213356, rs25487 and rs1799782) in XRCC1, and three SNPs (rs1799794, rs861531 and rs861530) in XRCC3 showed significant associations with the risk of bladder cancer.
|
27153553 |
2016 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to examine the association between polymorphisms of DNA repair genes, namely X-ray repair cross-complementing group I (XRCC1) rs2854509 and rs3213255, and bladder cancer recurrence risk.
|
25616696 |
2015 |
Bladder Neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polymorphism of DNA repair genes OGG1, XRCC1, XPD and ERCC6 in bladder cancer in Belarus.
|
25089939 |
2014 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The analysis suggests that the XRCC1 Arg399Gln polymorphism might be a moderate risk factor for bladder cancer, especially in non-Asian population.
|
24176953 |
2014 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DNA adducts were instead positively associated with occupational cumulative exposure to AAs (p = 0.028), whereas XRCC1 Arg 399 (p<0.006) was related with a decreased adduct levels, but with no impact on BC risk.
|
24722645 |
2014 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We identified no association between the XRCC1 Arg399Gln polymorphism and bladder cancer risk.
|
25501209 |
2014 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the XRCC1 gene modify survival of bladder cancer patients treated with chemotherapy.
|
23553206 |
2013 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variants in the XRCC1 gene might alter protein structure or function or create alternatively spliced proteins which may influence BER efficiency and hence affect individual susceptibility to bladder cancer.
|
24039945 |
2013 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the results of the present study suggest that XRCC1 Arg399Gln polymorphism might not modify the susceptibility to bladder cancer.
|
23479765 |
2013 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggested that XRCC1 Arg194Trp and Arg280His polymorphisms were risk factors for increasing bladder cancer in Asian population.
|
24266849 |
2013 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This is the first meta-analysis conducted in Asian investigating the correlation between XRCC1 polymorphisms and susceptibility to bladder cancer.
|
23704969 |
2013 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Crude odds ratios with 95% confidence intervals were used to assess the associations between XRCC1 Arg194Trp and Arg399Gln polymorphisms and bladder cancer risk.
|
23496911 |
2013 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis results suggest that XRCC1 Arg194Trp and Arg280His polymorphisms are associated with significantly increased risk of bladder cancer in Asians.
|
23636799 |
2013 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haplotype of XRCC1 also associated with significant risk for PCa and BC.
|
22019847 |
2012 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined the associations between bladder cancer and 7 polymorphisms from 5 genes involved in the maintenance of genetic stability (MMR: MLH1-93G>A; BER: XRCC1--77T>C and Arg399Gln; NER:XPC Lys939Gln and PAT +/-; DSBR:ATM G5557A and XRCC7 G6721T) in 302 incident bladder cancer cases and 311 hospital controls.
|
22927776 |
2012 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No association was found between bladder cancer risk and the XRCC1 399 polymorphism. p53 mutations were found in 20.1% (35/174) patients.
|
20514470 |
2010 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that the XRCC1 and APE1 polymorphisms may contribute to susceptibility to bladder cancer.
|
20218899 |
2010 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Bladder cancer, GSTs, NAT1, NAT2, SULT1A1, XRCC1, XRCC3, XPD genetic polymorphisms and coffee consumption: a case-control study.
|
18365755 |
2008 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we recruited 251 bladder cancer cases and 251 healthy controls to evaluate the effect of hOGG1 codon 326 and XRCC1 codon 399 polymorphisms on bladder cancer.
|
18272472 |
2008 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Further studies based on larger, stratified population were required to explore the role of XRCC1 polymorphisms in bladder cancer risk.
|
18765423 |
2008 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No association was found between the polymorphisms in XRCC1 (Arg(194)Trp, Arg(280)His, Arg(399)Gln) and bladder cancer susceptibility.
|
18336890 |
2008 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further studies based on larger, stratified population were required to explore the role of XRCC1 polymorphisms in bladder cancer risk.
|
18765423 |
2008 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
In this study, we recruited 251 bladder cancer cases and 251 healthy controls to evaluate the effect of hOGG1 codon 326 and XRCC1 codon 399 polymorphisms on bladder cancer.
|
18272472 |
2008 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In order to examine the association of common genetic variation in the base-excision repair (BER) pathway with bladder cancer risk, we analyzed 43 single nucleotide polymorphisms (SNPs) in 12 BER genes (OGG1, MUTYH, APEX1, PARP1, PARP3, PARP4, XRCC1, POLB, POLD1, PCNA, LIG1, and LIG3).
|
17203305 |
2007 |