XRCC1, X-ray repair cross complementing 1, 7515

N. diseases: 410; N. variants: 39
Disease: Lung Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.100 GeneticVariation group BEFREE Previous studies have suggested that certain genetic polymorphisms, specifically the Xeroderma pigmentosum group D (XPD) gene codon 751 and the X-ray repair cross-complementing group 1 (XRCC1) gene codon 399 polymorphisms, were associated with an increased risk of lung cancer, and, in some studies, with a greater risk for mutations in the p53 tumor suppressor gene in lung tumors. 20514470 2010
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.100 GeneticVariation group LHGDN Association of DNA repair gene XRCC1 and lung cancer susceptibility among nonsmoking Chinese women. 19061777 2009
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.100 GeneticVariation group LHGDN Haplotypes of nine single nucleotide polymorphisms on chromosome 19q13.2-3 associated with susceptibility of lung cancer in a Chinese population. 18358500 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.100 GeneticVariation group LHGDN XRCC1 polymorphisms, cooking oil fume and lung cancer in Chinese women nonsmokers. 18407370 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.100 GeneticVariation group LHGDN XRCC1 polymorphism and lung cancer risk. 18999926 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.100 GeneticVariation group LHGDN Prospective assessment of XPD Lys751Gln and XRCC1 Arg399Gln single nucleotide polymorphisms in lung cancer. 17504986 2007
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.100 GeneticVariation group LHGDN Contrasting impact of DNA repair gene XRCC1 polymorphisms Arg399Gln and Arg194Trp on the risk of lung cancer in the north-Indian population. 17417947 2007
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.100 Biomarker group BEFREE In order to determine whether genetic polymorphisms affecting DNA repair capacity modulate p53 mutations in lung tumors from never-smokers, we compared p53 mutations with genotypes of XPD 312, XPD 751, and XRCC1 399 in lung tumors from 43 lifetime never-smokers. p53 mutations were identified in 10 (23%) cases and consisted mostly of G/C to A/T transitions. 16865671 2006
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.100 GeneticVariation group LHGDN A promoter polymorphism (-77T>C) of DNA repair gene XRCC1 is associated with risk of lung cancer in relation to tobacco smoking. 15970793 2005
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.100 GeneticVariation group LHGDN Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China. 15816625 2005
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.100 GeneticVariation group BEFREE Influence of common XPD and XRCC1 variant alleles on p53 mutations in lung tumors. 12552590 2003
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.100 GeneticVariation group BEFREE Lung tumors from 204 smokers with non-small cell lung cancer (NSCLC) were analyzed for mutations in exons 5-8 of the p53 gene and genotypes of XPD and XRCC1. p53 mutations were found in 20% (40/204) of the patients. 12844488 2003
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.100 GeneticVariation group LHGDN Polymorphisms in the DNA repair genes XRCC1 and ERCC2, smoking, and lung cancer risk. 12692111 2003
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.100 GeneticVariation group LHGDN DNA repair gene XRCC1 and XPD polymorphisms and risk of lung cancer in a Chinese population. 12151350 2002