Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
SIRT1 deacetylated and stabilized XRCC1 to promote chemoresistance in lung cancer.
|
31043584 |
2019 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To analyze the relationship of GSTT1, GSTM1, XRCC1 (rs25487), ERCC1 (rs11615, rs3212986), ERCC2 (rs13181), XRCC3 (rs861539), OGG1 (rs1052133), and Alpha-1-Antitrypsin mutations (AAT) with the risk of lung cancer in never-smokers, and ascertain if there is an effect modification between these polymorphisms and residential radon exposure.
|
31446980 |
2019 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using the multifactor dimensionality reduction method, we found a model of gene-gene interactions associated with the risk of lung cancer: NBS1 (rs1805794)-XRCC1 (rs25487)-hOGG1 (rs1052133)-XPG (rs17655).
|
31584889 |
2019 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CONCLUSIONS Taken together, T-77C and Arg399Gln polymorphisms of the XRCC1 gene, as well as the 186C>T and Val158Met polymorphisms of the COMT gene, increased the risk of lung cancer in non-smoking women, with the factors of occupation type, cooking-oil fumes, and soot exposures representing key contributing factors.
|
30109864 |
2018 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A significant association was found between SULT1A1 rs9282861 and XRCC1 rs25487 polymorphisms and lung cancer risk.
|
29110586 |
2017 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The polymorphic variants within the XRCC1 gene have found to play an important role in overall survival of lung cancer patients undergoing specific chemotherapy regimen.
|
28332164 |
2017 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haplotype analysis illustrated haplotype block 11 (CGAGG) carrying minor allele for XRCC1 206 was associated with the highest risk towards lung cancer on the contrary block 4 (CAGAG) carrying mutant allele for XRCC1 399 significantly decreased the risk.
|
27707541 |
2016 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to analyze the potential association between the c.1804C>A genetic variant of XRCC1 and lung cancer susceptibility.
|
27323144 |
2016 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Xeroderma pigmentosum group D (XPD) and X-ray repair cross-complementing 1 (XRCC1) genes are 2 important susceptibility genes related to lung cancer.
|
25308691 |
2016 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
XRCC1 is an important scaffold protein involved in base excision repair and plays an important role in the development of lung cancer.
|
27026405 |
2016 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Carriers of rs4646903 in CYP1A1, rs1048943 in CYP1A1, rs1695 in GSTP1, rs13181 in ERCC2, and rs25487 in XRCC1 are more likely to develop lung cancer.
|
27819744 |
2016 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Their results suggest that codon 399 polymorphism of XRCC1 gene might contribute to individual's susceptibility to lung cancer in Asian population and especially in nonsmoking Chinese women.The result is encouraging.
|
25835974 |
2015 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, these preliminary results suggest that the C > T, rs1799782 and C > T, rs25487 of XRCC1 genetic variants might be used as molecular markers for detecting lung cancer susceptibility.
|
25563194 |
2015 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
XRCC1 rs25487 polymorphism is associated with lung cancer risk in epidemiologically susceptible Chinese people.
|
26634519 |
2015 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These preliminary results suggested that the XRCC1 c.482C>T and c.1686C>G genetic variants might play genetic effects on the susceptibility to lung cancer in the studied population.
|
25433331 |
2015 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
XRCC1 is an important scaffold protein involved in base excision repair that is regulated by ERK1/2 and AKT signals and plays an important role in the development of lung cancer.
|
26046675 |
2015 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Additionally, four polymorphisms of XRCC1 (rs25487, rs25489, rs1799782, and rs3213245), which were investigated with regard to their association with lung cancer risk in previous studies, were also genotyped.
|
25592768 |
2015 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
When stratified by source of control, we observed an increased lung cancer risk among subjects carrying XRCC1 codon 399 Arg/Gln+Gln/Gln genotype on the basis of hospitalized patient-based controls (OR=1.21, 95%CI: 1.04-1.42) and among subjects carrying XRCC1 codon 399 Gln/Gln genotype on the basis of healthy subject-based controls (OR=1.22, 95%CI: 1.04-1.43).
|
25684477 |
2015 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we investigated the polymorphisms of the following selected members of the base and nucleotide excision repair genes: XPC (Lys939Gln), XPD (Lys751Gln), XRCC1(Arg399Gln), and hOGG1(Ser326Ser), and the risk they present toward the development of lung cancer, with emphasis on the effect of chromium exposure.
|
25300687 |
2015 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Gln/Gln alleles of both XRCC1 and XPD genes appear to amplify the effects of household exposure, smoking and betel quid chewing on lung cancer risk in the study population.
|
24716924 |
2014 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The influence of XRCC1 gene on the susceptibility to lung cancer was analyzed by the analyses association.
|
24519065 |
2014 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study confirms that xrcc1 rs1799782 may lower the risk of lung cancer among Caucasians.
|
25038912 |
2014 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that three variants in CYP1A1, GSTM1, and XRCC1 showed consistently significant associations with lung cancer in mixed analysis and stratified analysis, and several variants showed diverse effects interacting with different environmental factors in stratified analysis.
|
24515656 |
2014 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These preliminary results suggested that the XRCC1 c.1178G>A genetic polymorphism is statistically associated with lung cancer risk in the Chinese population.
|
24935603 |
2014 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis has demonstrated that codon 399 polymorphism of XRCC1 gene might contribute to individual's susceptibility to lung cancer in Asian population, and especially in nonsmoking Chinese women.
|
23943371 |
2014 |