XRCC1, X-ray repair cross complementing 1, 7515

N. diseases: 410; N. variants: 39
Disease: Head and Neck Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma 		0.100 Biomarker disease BEFREE Evaluation of XRCC1 Gene Polymorphism as a Biomarker in Head and Neck Cancer Patients Undergoing Chemoradiation Therapy. 29893275 2018
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma 		0.100 GeneticVariation disease BEFREE Our meta-analysis suggested that the XRCC1 Arg399Gln polymorphism was not a risk factor for HNC susceptibility. 24694255 2014
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma 		0.100 GeneticVariation disease BEFREE This meta-analysis suggests that the XRCC1 Arg194Trp polymorphism is a risk factor for head and neck cancer in Asian populations. 25062722 2014
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma 		0.100 GeneticVariation disease BEFREE These data suggest that the XRCC1 Arg399Gln polymorphism is associated with an increased risk of developing HNC, because it correlates with occupational exposure in Tunisian population. 24020925 2014
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma 		0.100 GeneticVariation disease BEFREE The XRCC1 Arg194Trp polymorphism was significantly associated with HNC risk in studies that were adjusted for smoking and alcohol under the homozygous and heterozygote models. 24497981 2014
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma 		0.100 GeneticVariation disease BEFREE PCR-single-strand conformation polymorphism and DNA sequencing were used to analyze the whole exonic region of XRCC1 in head and neck cancer patients. 23055018 2013
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma 		0.100 GeneticVariation disease BEFREE Overall, no evidence of significant association was observed between XRCC1 Arg194Trp, XRCC1 Arg280His, XRCC1 Arg399Gln genotypes and the risk of HNC in any genetic models. 24086310 2013
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma 		0.100 Biomarker disease BEFREE Associated risk of XRCC1 and XPD cross talk and life style factors in progression of head and neck cancer in north Indian population. 21945240 2012
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma 		0.100 Biomarker disease BEFREE In this study, we have found that the deregulation of BER genes (XRCC1 and OGG1) in relation to excessive proliferation (as measured by proliferation marker Ki-67) may be considered as important factors in the development of head and neck cancer in Pakistani population. 22798271 2012
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma 		0.100 GeneticVariation disease BEFREE Association between single nucleotide polymorphisms in the XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer. 21704413 2011
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma 		0.100 GeneticVariation disease BEFREE Marginally statistically significant association was found for XRCC1 codon 399 (for Caucasians only), XPD Asp312Asn and XRCC1 codon 194 variants and head and neck cancer. 20429839 2010
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma 		0.100 GeneticVariation disease BEFREE Because of the important role of the XRCC1 gene in DNA repair, we wanted to test the effects of the Arg194Trp and Arg399Gln polymorphisms of XRCC1 on the clinical outcome of head and neck cancer. 19846968 2009
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma 		0.100 GeneticVariation disease BEFREE Polymorphisms of XRCC1, FGFR, and CCND1 have been consistently associated with HNC survival in at least two studies, whereas most of the other polymorphisms have either conflicting data or were from single studies. 18349267 2008
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma 		0.100 GeneticVariation disease BEFREE Polymorphisms of the XRCC1 DNA repair gene in head and neck cancer. 15800678 2005
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma 		0.100 GeneticVariation disease BEFREE Pooling data and DNA specimens from three case-control studies in western Washington State, North Carolina, and Puerto Rico, totaling 555 cases (430 whites) and 792 controls (695 whites), we studied the risk of head and neck cancer in relation to common nonsynonymous single-nucleotide polymorphisms in four DNA repair genes: MGMT (Leu84Phe and Ile143Val), XRCC1 (Arg399Gln), XPD (Lys751Gln), and XRCC3 (Thr241Met). 16030112 2005
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma 		0.100 GeneticVariation disease BEFREE Association of DNA repair gene XRCC1 polymorphisms with head and neck cancer in Korean population. 15252855 2004
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma 		0.100 GeneticVariation disease BEFREE XRCC1 polymorphisms and head and neck cancer. 11867203 2002