|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recent studies have described the critical functions of Zic proteins in cancers and the potential tumor-suppressive functions in colon cancer development and progression.
|
31392276 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study revealed that glioma cells can be reprogrammed into neuron-like cells using a single factor ZIC1, which may be a potential tumor suppressor gene for gliomas treatment.
|
30264483 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Only ZIC1 expression in normal tissues was obviously higher than that in tumors (<i>p</i><0.001).
|
29628984 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
On the whole, the findings of this study demonstrate that ZIC1 plays a tumor suppressive role in breast cancer, by targeting surviving, significantly downregulating its expression.
|
29956756 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Zic1 is a novel candidate tumor suppressor gene that is epigenetically silenced in GC.
|
26207911 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Methylation frequency of ZIC1 in HCC was significantly higher than that in the corresponding noncancerous tissues (P < 0.001), and it was correlated with tumor size (P = 0.022), histological differentiation (P = 0.033), and tumor stage (P = 0.009).
|
24782033 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ZIC1 is a putative tumor suppressor in thyroid cancer by modulating major signaling pathways and transcription factor FOXO3a.
|
24684457 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ZIC1, a potential tumor suppressor gene involved in regulating cell growth and apoptosis, was investigated in MPM cell lines and tumors.
|
24457242 |
2013 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Methylation of ZIC1, a putative tumor suppressor, may be a novel determinant of OC outcome.
|
23774800 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We previously showed that ZIC1 may function as a tumour suppressor in gastrointestinal cancers.
|
22799764 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
ZIC1 is downregulated through promoter hypermethylation, and functions as a tumor suppressor gene in colorectal cancer.
|
21347233 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results revealed ZIC1 as a novel candidate tumor suppressor gene downregulated through promoter hypermethylation in gastric cancer.
|
19135984 |
2009 |