|
Abnormal behavior
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Behavioral abnormalities of Zic1 and Zic2 mutant mice: implications as models for human neurological disorders.
|
11699604 |
2001 |
|
Abnormal behavior
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Zic2(kd/+) mice showed increased locomotor activity in novel environments, cognitive and sensorimotor gating dysfunctions, and social behavioral abnormalities.
|
22355535 |
2011 |
|
Acrania
|
0.300 |
Biomarker
|
disease |
CTD_human |
Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives.
|
15136147 |
2004 |
|
Adult Liver Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, using expression profiling and CRISPR-interference assays with clinical samples of human liver cancers, we identified a long noncoding RNA (lncRNA), lncZic2, that is located near the ZIC2 locus and was highly expressed in liver cancer and liver TICs.
|
29588366 |
2018 |
|
Agenesis of corpus callosum
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Alobar Holoprosencephaly
|
0.300 |
GermlineCausalMutation
|
disease |
ORPHANET |
|
|
|
|
Ambiguous Genitalia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical analyses further supported the correlation of ZIC2 expression and these genes in human pancreata harboring PDAC.
|
26318045 |
2015 |
|
Anteverted nostril
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Arachnoid Cysts
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These findings expanded the spectrum of the ZIC2 gene mutations and associated clinical manifestations, which is the first identification of a mutated ZIC2 gene in a Han infant girl with mild microcephaly, semilobor HPE, and arachnoid cyst.
|
30855487 |
2019 |
|
Asplenia Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A strong bias towards right isomerism indicates a failure to establish left identity in the lateral plate mesoderm (LPM), a phenotype that cannot be explained simply by the defective ciliogenesis previously noted in Zic2 mutants.
|
29992973 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Ataxia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
In previous studies, we showed that the homozygous Zic1 null mutation (Zic1-/-) results in cerebellar malformation with severe ataxia and that holoprosencephaly and spina bifida occur in homozygotes for Zic2 knockdown mutation (Zic2kd/kd).
|
11699604 |
2001 |
|
Autism Spectrum Disorders
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that EZH2 is involved in regulating ZIC2 and SHANK1 which have been linked to neurological diseases such as autism spectrum disorder.
|
28720872 |
2017 |
|
Bifid nose
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We report on a patient with holoprosencephaly caused by a rare ZIC2 mutation presenting a bifid nose associated with a nasal fistula and an epidermal cyst, besides hypernatremia.
|
30894326 |
2020 |
|
Broad forehead
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Carcinogenesis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
We found that lncZic2 is required for the self-renewal of liver TICs in a ZIC2-independent manner. lncZic2 drove the expression of myristoylated alanine-rich protein kinase C substrate (MARCKS) and MARCKS-like 1 (MARCKSL1), whose expression levels were increased during liver tumorigenesis and liver TIC self-renewal.
|
29588366 |
2018 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The zinc finger gene ZIC2 has features of an oncogene and its overexpression correlates strongly with the clinical course of epithelial ovarian cancer.
|
22733541 |
2012 |
|
Cerebellar Ataxia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
In previous studies, we showed that the homozygous Zic1 null mutation (Zic1-/-) results in cerebellar malformation with severe ataxia and that holoprosencephaly and spina bifida occur in homozygotes for Zic2 knockdown mutation (Zic2kd/kd).
|
11699604 |
2001 |
|
cervical cancer
|
0.020 |
Biomarker
|
disease |
BEFREE |
Hence, the aim of the present study was to evaluate the ability of miR-129-5p to influence cell angiogenesis, invasion and migration by targeting ZIC2 through the Hedgehog signaling pathway in CC.
|
30260270 |
2018 |
|
cervical cancer
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results also suggested that centromere protein M, methionine sulfoxide reductase B3 and Zic family member 2 could be promising biomarkers for the prognosis of cervical cancer.
|
31612001 |
2019 |
|
Cervix carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results also suggested that centromere protein M, methionine sulfoxide reductase B3 and Zic family member 2 could be promising biomarkers for the prognosis of cervical cancer.
|
31612001 |
2019 |
|
Cervix carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Hence, the aim of the present study was to evaluate the ability of miR-129-5p to influence cell angiogenesis, invasion and migration by targeting ZIC2 through the Hedgehog signaling pathway in CC.
|
30260270 |
2018 |
|
Childhood Medulloblastoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Additional analysis of 18 sporadic medulloblastomas revealed an overall correlation between highly methylated tumors and poor clinical outcome and identified ZIC2 as a frequently methylated gene in pediatric medulloblastoma.
|
17344319 |
2007 |
|
Childhood Osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We first showed that ZIC2 is highly expressed in osteosarcoma cells and tissues.
|
28857346 |
2018 |