ZIC3, Zic family member 3, 7547

N. diseases: 93; N. variants: 19
Disease: Heterotaxy Syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3178805
Disease: Heterotaxy Syndrome
Heterotaxy Syndrome 		0.520 GeneticVariation disease BEFREE Moreover, morpholino-knockdown experiments in zebrafish demonstrated that zic3 mutant mRNA failed to rescue the abnormal phenotype, suggesting a role for the novel ZIC3 mutation in heterotaxy syndrome. 30120289 2018
CUI: C3178805
Disease: Heterotaxy Syndrome
Heterotaxy Syndrome 		0.520 Biomarker disease MGD Zic3 is required in the migrating primitive streak for node morphogenesis and left-right patterning. 23303524 2013
CUI: C3178805
Disease: Heterotaxy Syndrome
Heterotaxy Syndrome 		0.520 Biomarker disease BEFREE Zinc fingers in cerebellum 3 (ZIC3) was the first gene to be definitively associated with heterotaxy syndromes in humans (OMIM #306955), with 13 mutations previously described in both familial and sporadic cases. 22171628 2013
CUI: C3178805
Disease: Heterotaxy Syndrome
Heterotaxy Syndrome 		0.520 Biomarker disease MGD Zic3 is required in the extra-cardiac perinodal region of the lateral plate mesoderm for left-right patterning and heart development. 23184148 2013
CUI: C3178805
Disease: Heterotaxy Syndrome
Heterotaxy Syndrome 		0.520 Biomarker disease MGD A complex syndrome of left-right axis, central nervous system and axial skeleton defects in Zic3 mutant mice. 11959836 2002
CUI: C3178805
Disease: Heterotaxy Syndrome
Heterotaxy Syndrome 		0.520 Biomarker disease MGD The X-linked mouse mutation Bent tail is associated with a deletion of the Zic3 locus. 10942421 2000
CUI: C3178805
Disease: Heterotaxy Syndrome
Heterotaxy Syndrome 		0.520 Biomarker disease MGD A deletion encompassing Zic3 in bent tail, a mouse model for X-linked neural tube defects. 10861288 2000
CUI: C3178805
Disease: Heterotaxy Syndrome
Heterotaxy Syndrome 		0.520 Biomarker disease MGD The interfrontal bone and mutant genes in the mouse. 1018005 1976
CUI: C3178805
Disease: Heterotaxy Syndrome
Heterotaxy Syndrome 		0.520 Biomarker disease MGD """Bent-Tail,"" A Dominant, Sex-Linked Mutation in the Mouse." 16589192 1952
CUI: C3178805
Disease: Heterotaxy Syndrome
Heterotaxy Syndrome 		0.520 Biomarker disease GENOMICS_ENGLAND