|
Steatohepatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The present results suggest that chronic treatment with mLXT ameliorates olanzapine-induced fatty liver by regulating hepatic de novo lipogenesis- and fatty acid beta-oxidation-associated gene expression mediated by SREBP-1c and PPAR-alpha, respectively, through activation of AMPK-alpha.
|
30590197 |
2019 |
|
Steatohepatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, during ER stress, BDNF<sup>(+/-)</sup>+Tm group showed increased apoptosis, GADD153 immunostaining, sterol regulatory element-binding protein-1c (SREBP-1c) level, and steatosis compared to the WT + Tm group.
|
30039987 |
2019 |
|
Steatohepatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CypD stimulates mPTP excessive opening, subsequently causing endoplasmic reticulum stress through p38 mitogen-activated protein kinase activation, and results in enhanced sterol regulatory element-binding protein-1c transcription and hepatic steatosis.(Hepatology 2018;68:62-77).
|
29356058 |
2018 |
|
Steatohepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The differences in hepatic gene expression and peroxisomal protein patterns were surprisingly small between the control and alb-SREBP-1a mice, although the latter develop a severe phenotype with visceral obesity and fatty liver.
|
29587401 |
2018 |
|
Steatohepatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we report the effects of DPT in the fatty liver induced by high fat diet in vivo as well as its regulatory mechanism related with the transcription factor for lipogenic genes such as sterol regulatory element binding protein-1c (SREBP-1c) in vitro.
|
30148990 |
2018 |
|
Steatohepatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ACH09 reduced the expression of the lipogenic factor sterol regulatory-element binding protein-1c in the liver and upregulated the lipolytic pathway (phosphorylated liver kinase B1/phosphorylated adenosine-monophosphate-activated protein kinase), which was associated with normal hepatic levels of triglyceride and cholesterol and prevention of steatosis.
|
28739056 |
2017 |
|
Steatohepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Sterol regulatory element-binding protein-1c (Srebp-1c), a master transcription factor of fatty acid (FA) biosynthesis, is responsible for the pathogenesis of fatty liver (steatosis).
|
28256090 |
2017 |
|
Steatohepatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The main purpose of this study was to investigate whether LBP prevented fatty liver through activation of adenosine monophosphate-activated protein kinase (AMPK) and suppression of sterol regulatory element-binding protein-1c (SREBP-1c).
|
25013763 |
2014 |
|
Steatohepatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and apoptosis.
|
22742899 |
2012 |
|
Steatohepatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Liver X receptor-α (LXRα) functions as a major regulator of lipid homeostasis through activation of sterol regulatory element binding protein-1c (SREBP-1c), which promotes hepatic steatosis and steatohepatitis.
|
20677908 |
2011 |
|
Steatohepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that the LXRα gene and its lipogenic targets PPAR-γ (peroxisome-proliferator-activated receptor-γ), SREBP (sterol-regulatory-element-binding protein)-1c, SREBP-2 and FAS (fatty acid synthase) were overexpressed in the liver of NAFLD and HCV patients who had steatosis.
|
20929443 |
2011 |
|
Steatohepatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In patients with HCV, a significant negative relationship was seen between hepatic SREBP-1c mRNA expression and grade of steatosis (r(s)=-0.28, p=0.002), stage of fibrosis (r(s)=-0.375, p<0.001) and severity of inflammation (r(s)=-0.313, p<0.001).
|
18752865 |
2008 |
|
Steatohepatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hepatic expression of sterol regulatory element binding protein-1c (SREBP-1c), which plays a major role in hepatic steatosis, is regulated by multiple factors, including insulin, adenosine monophosphate-activated protein kinase (AMPK), liver X receptors (LXRs), and specificity protein 1.
|
18972440 |
2008 |
|
Steatohepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The transgenic SHR overexpressing SREBP-1a represents a nonobese rat model of fatty liver, disordered glucose and lipid metabolism, and hypertension that may provide new opportunities for studying the pathogenesis and treatment of the metabolic syndrome associated with hepatic steatosis.
|
15809359 |
2005 |