|
Dysferlinopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Western blotting revealed that creatine kinase M-type, carbonic anhydrase III (muscle specific) and desmin were significantly elevated in dysferlinopathy muscle.
|
31439488 |
2020 |
|
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition to the effect of introducing CAIII into cardiomyocytes on maintaining homeostasis to counter acidotic stress, the results demonstrate the role of carbonic anhydrases in maintaining intracellular pH in muscle cells as a potential mechanism to treat heart failure.
|
31390226 |
2019 |
|
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition to the effect of introducing CAIII into cardiomyocytes on maintaining homeostasis to counter acidotic stress, the results demonstrate the role of carbonic anhydrases in maintaining intracellular pH in muscle cells as a potential mechanism to treat heart failure.
|
31390226 |
2019 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
At acidotic pH, however, CAIII transgenic mouse hearts showed significantly less decrease in cardiac function than that of wild-type control as shown by higher ventricular pressure development, systolic and diastolic velocities, and stroke volume via elongating the time of diastolic ejection.
|
31390226 |
2019 |
|
Febrile Convulsions
|
0.010 |
Biomarker
|
disease |
BEFREE |
Temporal analysis of hippocampal CA3 gene coexpression networks in a rat model of febrile seizures.
|
29196444 |
2018 |
|
Deglutition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Lyophilized CAR: CS 1:3 (sample DL13), MET:CS 1:3 (sample DL8) and MET:CAR 3:1 (sample DL1) wafers seem to be a very promising system for the administration of low dose aspirin for older patients with dysphagia.
|
30312748 |
2018 |
|
Sore to touch
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
PIF analysis identified myoglobin (<i>MB</i>), enolase 3 (<i>ENO3</i>), and carbonic anhydrase 3 (<i>CA3</i>) as potentially having fundamental roles in tenderness.
|
30344530 |
2018 |
|
Myasthenia Gravis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our study illustrates that skeletal muscle cell CAR3 is critical for CHRN homeostasis in the neuromuscular junction, and its deficiency leads to accelerated degradation of CHRN and development of myasthenia gravis, potentially revealing a novel therapeutic approach for this disorder.
|
28933591 |
2017 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
M12 is the first peptide associated with the CAIII protein that may be used as an antigen for antibody detection to aid in RA diagnosis with high sensitivity and specificity.
|
26099944 |
2015 |
|
Laryngeal Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Carbonic anhydrase III levels vary in the larynx in response to laryngopharyngeal reflux, depending on location.
|
21914248 |
2011 |
|
Laryngopharyngeal Reflux
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Carbonic anhydrase III levels vary in the larynx in response to laryngopharyngeal reflux, depending on location.
|
21914248 |
2011 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Silencing of FAK expression in CAIII transfectants led to suppression of HCC cell invasion.
|
18444244 |
2008 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
LHGDN |
Serum myoglobin/carbonic anhydrase III ratio in the diagnosis of perioperative myocardial infarction during coronary bypass surgery.
|
12745799 |
2003 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, the reduction of CAI, CAII and CAIII in HCC tumor areas was also revealed in this study and this reduction might promote tumor cell motility and contribute to tumor growth and metastasis.
|
12927591 |
2003 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, the reduction of CAI, CAII and CAIII in HCC tumor areas was also revealed in this study and this reduction might promote tumor cell motility and contribute to tumor growth and metastasis.
|
12927591 |
2003 |
|
Fatigue
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Mouse skeletal muscles lacking CAIII showed lower intracellular pH during fatigue, suggesting its function in stress tolerance.
|
31390226 |
2019 |
|
Fatigue
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Specifically, the change in the expression of CAIII reflected the conversion to type I myofibers, suggesting the importance of CAIII in resistance to fatigue in skeletal muscle.
|
28983629 |
2017 |
|
Muscular Dystrophy, Duchenne
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The difference between the CK and CAIII results could indicate biochemical heterogeneity in the expression of Duchenne muscular dystrophy.
|
3925781 |
1985 |
|
Muscular Dystrophy, Duchenne
|
0.020 |
Biomarker
|
disease |
BEFREE |
Fetal plasma carbonic anhydrase III in prenatal diagnosis of Duchenne muscular dystrophy.
|
3918446 |
1985 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Oral administration of JTC801 inhibited growth of xenograft tumors (from PANC1, MiaPaCa2, SK-MEL-28, PC-3, 786-0, SF-295, HCT116, OV-CAR3, and HuH7 cells), orthotropic tumors (from KPC cells), lung metastases (from KPC cells) of mice, and slowed growth of tumors in KCH mice.
|
29248440 |
2018 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
S100A10 (p11), major vault protein, guanylate-binding protein 1(GBP1), and carbonic anhydrase III (CAIII) were identified to have significantly increased expression in EGFRvIII expressing xenograft tumors relative to wtEGFR xenograft tumors.
|
22964225 |
2012 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Furthermore, the reduction of CAI, CAII and CAIII in HCC tumor areas was also revealed in this study and this reduction might promote tumor cell motility and contribute to tumor growth and metastasis.
|
12927591 |
2003 |
|
Glomerular Filtration Rate
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A catalog of genetic loci associated with kidney function from analyses of a million individuals.
|
31152163 |
2019 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |