Disease: Bipolar Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Our findings suggest a role of rs1034936 CACNA1C gene variant in BD-AA group. 31634677 2020
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease CTD_human Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. 18711365 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease GWASDB Finally, a combined GWAS analysis of schizophrenia and bipolar disorder yielded strong association evidence for SNPs in CACNA1C and in the region of NEK4-ITIH1-ITIH3-ITIH4. 21926972 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE In the present study, we tested the association of CACNA1C with MDD and BD in Han Chinese. 23680436 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Genomic wide association studies identified the CACNA1C locus as genetically associated with both schizophrenia and bipolar affective disorder. 29501388 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE The CACNA1C gene is strongly implicated in the etiology of multiple major neuropsychiatric disorders, such as bipolar disorder, major depression, and schizophrenia, with cognitive deficits being a common feature. 29800644 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE ANK3 and CACNA1C--missing genetic link for bipolar disorder and major depressive disorder in two German case-control samples. 22647524 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Genome-wide association studies have identified allelic variation in CACNA1C as a risk factor for multiple psychiatric disorders associated with limbic system dysfunction, including bipolar disorder, schizophrenia, and depression. 26401721 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Specifically, genome wide association studies (GWAS) have repeatedly identified the single nucleotide polymorphism (SNP) rs1006737 in intron 3 of CACNA1C to be strongly associated with schizophrenia and bipolar disorder. 27276213 2016
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. 18711365 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Strong evidence (P=7.0 × 10(-7)) of association at the polymorphism rs1006737 (within CACNA1C, the gene encoding the α-1C subunit of the L-type voltage-gated calcium channel) with the risk of bipolar disorder (BD) has recently been reported in a meta-analysis of three genome-wide association studies of BD, including our BD sample (N=1868) studied within the Wellcome Trust Case Control Consortium. 19621016 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Our findings implicate abnormal perigenual and hippocampal activation as a promising intermediate phenotype for psychiatric disease and suggest a pathophysiologic mechanism conferred by a CACNA1C variant being implicated in risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia. 24411473 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 AlteredExpression disease BEFREE Longitudinal expression of LTCC genes (CACNA1C, CACNA1D and CACNB3) was then measured over 12-24 h in BD and control cells. 26476274 2016
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease GWASDB Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample. 23070075 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Genetic variants in CACNA1C (calcium voltage-gated channel subunit alpha1 C) are associated with bipolar disorder and schizophrenia where sleep disturbances are common. 28792954 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE These results provide additional evidence that CACNA1C is associated with BP and provides the first evidence that variations in this gene might play a role in the pathogenesis of this disorder in the Latino population. 23437964 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE The CACNA1C gene that encodes the L-type Ca<sup>2+</sup> channel (LTCC) Ca<sub>v</sub>1.2 subunit has emerged as a candidate risk gene for multiple neuropsychiatric disorders including bipolar disorder, major depressive disorder, and schizophrenia, all marked with depression-related symptoms. 27922594 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Genotyping of five genome-wide significant variants identified for BD (in CACNA1C, ANK3, and ODZ4) was performed in 673 BPD cases and 748 controls. 25304227 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE CACNA1C rs1006737 genotype and bipolar disorder: Focus on intermediate phenotypes and cardiovascular comorbidity. 25976633 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE Collectively, these results reveal a significant association of CACNA1C with BD among the Pakistani population, extending results from other ethnic groups to the Pakistani population for the first time. 29684488 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Associations of two voltage-gated calcium channel (Cav) genes, CACNA1C and CACNB2, were identified for bipolar disorder (BP) in different ethnic groups in recent genome-wide association studies. 24581832 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Genome-wide studies have identified allele A (adenine) of single nucleotide polymorphism (SNP) rs1006737 of the calcium-channel CACNA1C gene as a risk factor for both schizophrenia (SZ) and bipolar disorder (BD) as well as allele A for rs1344706 in the ZNF804A gene. 27790829 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease PSYGENET Genotyping of five genome-wide significant variants identified for BD (in CACNA1C, ANK3, and ODZ4) was performed in 673 BPD cases and 748 controls. 25304227 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE However, as the ADRB2 gene product directly interacts with the CACNA1C gene product, and is known to be implicated in BD susceptibility, we conclude that further exploration of the relationships between ADRB2 and BD needs to be undertaken. 22628130 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease GWASDB Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate. 23637625 2013