Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease CTD_human Single-nucleotide polymorphisms (SNPs) in CACNA1C, the α1C subunit of the voltage-gated L-type calcium channel Ca<sub>v</sub>1.2, rank among the most consistent and replicable genetics findings in psychiatry and have been associated with schizophrenia, bipolar disorder and major depression. 28696432 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease PSYGENET Our findings implicate abnormal perigenual and hippocampal activation as a promising intermediate phenotype for psychiatric disease and suggest a pathophysiologic mechanism conferred by a CACNA1C variant being implicated in risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia. 24411473 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease PSYGENET Since CACNA1C variants have been associated repeatedly with psychosis at a genome-wide level, and preclinical data provide convergent evidence for the relevance of the CACNA1C gene for hippocampal and frontolimbic plasticity and adaptive regulation of stress, our data suggest a potential pathophysiological mechanism conferred by CACNA1C variants that may mediate risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia. 24642287 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease PSYGENET Our findings support CACNA1C being a risk gene for both schizophrenia and major depressive disorder in the Han Chinese population. 24262814 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease PSYGENET Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression. 24643163 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease PSYGENET Genetic variation in CACNA1C affects neural processing in major depression. 24612926 2014