ZYX, zyxin, 7791

N. diseases: 34; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0200641
Disease: Blood basophil count (lab test)
Blood basophil count (lab test)
0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 Biomarker group BEFREE LIM domains containing 1 (LIMD1) is a member of the Zyxin family proteins and functions as a tumor suppressor in lung cancer. 30600590 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 Biomarker group BEFREE Depletion of Zyxin resulted in significantly impaired colon cancer cell proliferation, migration, anchorage-independent growth, and tumor formation in xenograft animal models. 29967145 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 Biomarker group BEFREE The Zyxin family comprises seven homologous proteins involved in migration and proliferation of many cell types of which Zyxin has been described as a tumour suppressor in ES. 24033704 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 Biomarker group BEFREE Moreover, recurrence after resection was common in cases that displayed zyxin overexpressions in the initial resected tumor (P = 0.05). 16680155 2006
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 AlteredExpression group BEFREE We observe similar phenotypic changes after zyxin gene transfer in SK-N-MC cells, suggesting that zyxin has tumor suppressor activity in Ewing tumor cells. 15748890 2005
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.040 Biomarker phenotype BEFREE Altogether, our results suggest that ZYX defective binding to ACTN4, which occupies focal adhesions instead of ACTN1, induces the formation of immature focal adhesions, resulting in the enhancement of cell motility and invasion. 25860875 2015
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.040 AlteredExpression phenotype BEFREE The Zyxin-related protein thyroid receptor interacting protein 6 (TRIP6) is overexpressed in Ewing's sarcoma and promotes migration, invasion and cell growth. 24033704 2013
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.040 AlteredExpression phenotype BEFREE Knockdown of Zyxin expression by siRNA in fibroblastic type OSCC cells was associated with cell morphological changes from spindle (fibroblastic) to polygonal (epithelial) shape and significantly inhibited cell growth as well as cell migration and invasion. 23292068 2013
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.040 Biomarker phenotype BEFREE Functional examination of zyxin by small interfering RNA-mediated knockdown in Hep3B cell line indicated a significant inhibition on cell migration through porous membrane (P = 0.002) and invasion through matrigel-coated membrane (P = 0.005). 16680155 2006
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.030 Biomarker group BEFREE Zyxin as a potential cancer prognostic marker promotes the proliferation and metastasis of colorectal cancer cells. 30697742 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.030 Biomarker disease BEFREE Our results suggested that zyxin and nesprin-1 are not only promising therapeutic targets but also potential diagnostic biomarkers for colon cancer. 31501460 2019
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.030 Biomarker disease BEFREE Our results suggested that zyxin and nesprin-1 are not only promising therapeutic targets but also potential diagnostic biomarkers for colon cancer. 31501460 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.030 Biomarker group BEFREE Zyxin as a potential cancer prognostic marker promotes the proliferation and metastasis of colorectal cancer cells. 30697742 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.030 AlteredExpression disease BEFREE Zyxin regulates YAP activity through the colon cancer oncogene CDK8. 29967145 2018
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.030 AlteredExpression disease BEFREE Zyxin regulates YAP activity through the colon cancer oncogene CDK8. 29967145 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.030 Biomarker group BEFREE By regulating cell-cell junctions, integrin α5β1 expression, and cell-extracellular matrix adhesion, zyxin may regulate cancer cell motility and EMT during lung cancer development and progression. 22778267 2012
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.030 Biomarker group BEFREE By regulating cell-cell junctions, integrin α5β1 expression, and cell-extracellular matrix adhesion, zyxin may regulate cancer cell motility and EMT during lung cancer development and progression. 22778267 2012
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.030 Biomarker group BEFREE Here, we highlight the interesting member of the Zyxin family TRIP6 [thyroid receptor interactor protein 6; also designated ZRP-1 (zyxin-related protein 1)] and review current literature to define its role in cell physiology and cancer. 22054418 2011
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.030 Biomarker group BEFREE Here, we highlight the interesting member of the Zyxin family TRIP6 [thyroid receptor interactor protein 6; also designated ZRP-1 (zyxin-related protein 1)] and review current literature to define its role in cell physiology and cancer. 22054418 2011
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.030 Biomarker disease BEFREE In two of these data sets, one or two genes had relatively high frequencies not noticeable with rules involving 20 or 50 genes: desmin for classifying colon cancer versus normal tissue; and zyxin and secretory granule proteoglycan genes for classifying two types of leukemia. 16959042 2006
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.030 Biomarker disease BEFREE In two of these data sets, one or two genes had relatively high frequencies not noticeable with rules involving 20 or 50 genes: desmin for classifying colon cancer versus normal tissue; and zyxin and secretory granule proteoglycan genes for classifying two types of leukemia. 16959042 2006
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.020 Biomarker disease BEFREE Misregulation of nuclear functions of zyxin appears to be associated with pathogenic effects and diseases, such as prostate cancer and non-small-cell lung cancer. 30657586 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.020 AlteredExpression phenotype BEFREE Taken together, our findings provide the first evidence that decreased expression level of ZYX impairs CRC cell proliferation and metastasis probably via the FA pathway. 30697742 2019
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.020 Biomarker disease BEFREE LIM domains containing 1 (LIMD1) is a member of the Zyxin family proteins and functions as a tumor suppressor in lung cancer. 30600590 2019