ZYX, zyxin, 7791

N. diseases: 34; N. variants: 1
Disease: Ewings sarcoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0553580
Disease: Ewings sarcoma
Ewings sarcoma 		0.020 Biomarker disease BEFREE The Zyxin family comprises seven homologous proteins involved in migration and proliferation of many cell types of which Zyxin has been described as a tumour suppressor in ES. 24033704 2013
CUI: C0553580
Disease: Ewings sarcoma
Ewings sarcoma 		0.020 AlteredExpression disease LHGDN We observe similar phenotypic changes after zyxin gene transfer in SK-N-MC cells, suggesting that zyxin has tumor suppressor activity in Ewing tumor cells. 15748890 2005
CUI: C0553580
Disease: Ewings sarcoma
Ewings sarcoma 		0.020 Biomarker disease BEFREE In this work, we investigate the status of zyxin in Ewing tumors, a family of pediatric malignancies of bone and soft tissues, which are mainly associated with a t(11;22) chromosomal translocation encoding the EWS-FLI1 oncoprotein. 15748890 2005