Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.430 GeneticVariation disease BEFREE We replicated the association between DDR1 and SZ (rs1264323, adjusted P = 0.015). 30597424 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.430 GeneticVariation disease GWASCAT Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. 28540026 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.430 AlteredExpression disease BEFREE The discoidin domain receptor (DDR1) is highly expressed in oligodendrocytes during the neurodevelopmental myelination process and is genetically associated to schizophrenia. 18836851 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.430 GeneticVariation disease LHGDN In conclusion, we propose the DDR1 as a new susceptibility gene for schizophrenia. 17440435 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.430 Biomarker disease PSYGENET In conclusion, we propose the DDR1 as a new susceptibility gene for schizophrenia. 17440435 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.430 Biomarker disease BEFREE In conclusion, we propose the DDR1 as a new susceptibility gene for schizophrenia. 17440435 2007
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.350 Biomarker disease BEFREE DDR-Defective Metastatic Prostate Cancers Are Susceptible to Olaparib. 31836603 2020
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.350 Biomarker disease BEFREE In contrast, cell lines of colon and lung cancer did not reveal any sex-dependent difference in the correlation between DDR1 and ZEB1. 31807189 2019
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.350 Biomarker disease BEFREE Here, we provide novel evidence regarding the molecular mechanisms through which IGF-I/IGF-IR signaling triggers a functional cross-talk with GPER and DDR1 in both mesothelioma and lung cancer cells. 27384677 2016
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.350 Biomarker disease BEFREE Thus, minor Col IV α5(IV) chain supports lung cancer progression via DDR1-mediated cancer cell autonomous and non-autonomous mechanisms. 25992553 2015
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.350 Biomarker disease CTD_human The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response. 24763052 2014
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.350 AlteredExpression disease BEFREE DDR1 was expressed in a panel of human lung cancer cell lines, and high DDR1 levels in human lung tumors were associated with poor survival. 22223527 2012
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.350 Biomarker disease CTD_human Varied pathways of stage IA lung adenocarcinomas discovered by integrated gene expression analysis. 21552421 2011
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.350 AlteredExpression disease BEFREE Moreover, the expression of PCA-1 and DDR-1 was associated with a hormone-independent state of prostate cancer. 17970783 2008
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.350 GeneticVariation disease BEFREE To test whether the genetic variants of CAK genes modify the risk of lung cancer, we compared the manifestation of 25 single nucleotide polymorphisms (SNPs) and the haplotypes of Cdk7, MAT1 and cyclin H between 500 patients with lung cancer and 517 healthy controls. 17707548 2007
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.350 Biomarker disease BEFREE These experiments demonstrate that lentiviral NEP gene transfer is a novel targeted strategy for the treatment of NEP-deficient PC. 17415380 2007
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.350 Biomarker disease BEFREE Western blot experiments were performed using whole cell extracts to proof the presence of NEP protein in LNCaP and hPCPs. 14968440 2004
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.350 Biomarker disease BEFREE The results suggest that the analyzed structural motifs determine the subcellular distribution of NEP in epithelial LNCaP PC cells and stromal prostatic cells and therefore could be responsible for the altered cellular localization of NEP observed in PC. 14550292 2003
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.320 Biomarker group BEFREE Overall, our data suggest that IGF-I/IGF-IR system triggers stimulatory actions through both GPER and DDR1 in aggressive tumors as mesothelioma and lung tumors. 27384677 2016
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.320 AlteredExpression group BEFREE DDR1 was expressed in a panel of human lung cancer cell lines, and high DDR1 levels in human lung tumors were associated with poor survival. 22223527 2012
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.320 Biomarker group CTD_human Varied pathways of stage IA lung adenocarcinomas discovered by integrated gene expression analysis. 21552421 2011
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.310 Biomarker group CTD_human The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response. 24763052 2014
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.310 Biomarker group CTD_human Varied pathways of stage IA lung adenocarcinomas discovered by integrated gene expression analysis. 21552421 2011
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.310 AlteredExpression group BEFREE DDR1 up-regulation tend to be more frequently observed in invasive adenocarcinoma (64%) compared to DDR1 expression in BAC (38%) (p=0.056). 20596615 2010
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.310 Biomarker group LHGDN Prostate cancer antigen-1 contributes to cell survival and invasion though discoidin receptor 1 in human prostate cancer. 17970783 2008