Microphthalmos
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
PXDN mutations lead to severe eye disorders, including microphthalmia, cataract, glaucoma, and anterior segment dysgenesis in humans and mice.
|
31817535 |
2019 |
Irido-corneal dysgenesis
|
0.020 |
Biomarker
|
disease |
BEFREE |
We conclude that PXDN sequencing should be considered in microphthalmia with anterior segment dysgenesis.
|
24939590 |
2015 |
Irido-corneal dysgenesis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
PXDN mutations lead to severe eye disorders, including microphthalmia, cataract, glaucoma, and anterior segment dysgenesis in humans and mice.
|
31817535 |
2019 |
Autistic Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Results from this study indicate that the 2p25.3 duplication disrupting PXDN and MYT1L is a potential autism-causing variant in the pedigree reported here and should receive further consideration as a candidate for autism.
|
22157634 |
2012 |
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Role of vascular peroxidase 1 in senescence of endothelial cells in diabetes rats.
|
26142204 |
2015 |
Chronic Obstructive Airway Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The NADPH oxidase-ROS-NF-κB transduction pathway, VPO1, oxidative stress and their complicated interactions are implicated in the occurrence and development of COPD combined with PH.
|
28829513 |
2017 |
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study suggests that PXDN, NTN4 and GLIS3 play a functional role in promoting melanoma cellular invasion, and therapeutic approaches directed toward inhibiting the action of these proteins may reduce the incidence or progression of metastasis in melanoma patients.
|
27172792 |
2016 |
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, we conclude that VPO1 is a crucial regulator of cardiac fibrosis after MI by mediating HOCl/Smad2/3 and ERK1/2 signaling pathways, implying a promising therapeutic target in ischemic cardiomyopathy.
|
30844643 |
2019 |
Schizophrenia, Childhood
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We previously reported two patients with COS who carried a microduplication disrupting the PXDN and MYT1L genes at 2p25.3.
|
22547139 |
2012 |
Vasculitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, peroxidasin-specific antibodies were also found in serum from patients with anti-MPO vasculitis and were associated with significantly more active clinical disease.
|
30279272 |
2018 |
Aortic Aneurysm, Abdominal
|
0.010 |
Biomarker
|
disease |
BEFREE |
VPO1 Modulates Vascular Smooth Muscle Cell Phenotypic Switch by Activating Extracellular Signal-regulated Kinase 1/2 (ERK 1/2) in Abdominal Aortic Aneurysms.
|
30371171 |
2018 |
Ischemic cardiomyopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, we conclude that VPO1 is a crucial regulator of cardiac fibrosis after MI by mediating HOCl/Smad2/3 and ERK1/2 signaling pathways, implying a promising therapeutic target in ischemic cardiomyopathy.
|
30844643 |
2019 |
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, PXDN may be a biomarker associated with prostate cancer and a potential therapeutic target.
|
31234468 |
2019 |
Anti-Glomerular Basement Membrane Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
We determined whether autoantibodies directed against peroxidasin are also detected in GP.
|
30279272 |
2018 |
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, PXDN may be a biomarker associated with prostate cancer and a potential therapeutic target.
|
31234468 |
2019 |
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
We identified a novel 8.1-kb human melanoma gene, MG50, derived from subtractive hybridization with a squamous lung carcinoma cell line, LU-1.
|
11103812 |
2000 |
ovarian neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PXDN was highly expressed in OC tissues and cells.
|
29661721 |
2018 |
Malignant neoplasm of ovary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PXDN was highly expressed in OC tissues and cells.
|
29661721 |
2018 |
Congenital naevus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Of six normal tissues, MG50 was found only in a specimen of normal skin and was absent from a congenital nevus.
|
11103812 |
2000 |
Cardiac fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, we conclude that VPO1 is a crucial regulator of cardiac fibrosis after MI by mediating HOCl/Smad2/3 and ERK1/2 signaling pathways, implying a promising therapeutic target in ischemic cardiomyopathy.
|
30844643 |
2019 |
Progression of prostate cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, the data suggest that PXDN promotes progression of prostate cancer by regulating the metabolome, more specifically, by inhibiting oxidative stress leading to decreased apoptosis.
|
31234468 |
2019 |
Bilateral microphthalmos
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We re-examined exome data from 20 other patients with structural eye defects and identified two additional PXDN mutations in a sporadic male with bilateral microphthalmia, cataracts and anterior segment dysgenesis--a maternally inherited, frameshift mutation, c.1192delT, predicting p.(Tyr398Thrfs*40) and a paternally inherited, missense substitution that was predicted to be deleterious, c.947 A>C, predicting p.(Gln316Pro).
|
24939590 |
2015 |
Carcinoma, Ovarian Epithelial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PXDN was highly expressed in OC tissues and cells.
|
29661721 |
2018 |
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |