|
Nephroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pax8 and Pax2 showed an identical staining pattern, and were expressed in all (100%) WT while most CCSK were negative.
|
28426529 |
2019 |
|
Nephroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
She underwent a quadrantectomy (QSI) with an open biopsy of nodularity attached to the pectoral muscle fascia: on definitive histological characterization the breast lesions showed a high-grade invasive carcinoma, with papillary serum differentiation, and the immunohistochemistry study of breast lesion showed positivity for cytokeratin 7 and an extensive positivity for Wilm's tumor (WT)-1 and paired box 8 (PAX8).
|
30449229 |
2019 |
|
Nephroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry results demonstrated Calretinin (+), D2-40 (-), Ki-67 (10%+), Vimentin (-), CK-pan (+), CK5/6 (-), WT-1 (-), PSA (+), SALL4 (-), Villin (-), CK20 (-), CK7 (-), PAX-8 (-), and TTF-1 (-).
|
30558081 |
2018 |
|
Nephroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Paired box genes, PAX-2 and PAX-8, are not frequently mutated in Wilms tumor.
|
16814811 |
2006 |
|
Nephroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In cells transfected with PAX8-specific small interfering RNA, the stimulatory effects of hCG on WT1 mRNA levels were abolished, but hormonal enhancement of NIS mRNA levels was unchanged.
|
15961562 |
2005 |
|
Nephroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Possible regulation of Wilms' tumour gene 1 (WT1) expression by the paired box genes PAX2 and PAX8 and by the haematopoietic transcription factor GATA-1 in human acute myeloid leukaemias.
|
14531904 |
2003 |
|
Nephroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, we identified a novel functional binding site for the transcription factor PAX 8, suggesting that part of its role in kidney development may be as a modulator of WT1 expression in the kidney.
|
9388203 |
1997 |
|
Nephroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PAX8-mediated activation of the wt1 tumor suppressor gene.
|
8861958 |
1996 |
|
Nephroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have compared the expression patterns of PAX2, PAX8, and WT1 in fetal kidney and WTs by in situ hybridization.
|
7856737 |
1995 |
|
Nephroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
PAX2 and WT-1 expression were seen in all four primary WTs; PAX8 was seen in three of the four primary WTs.
|
7909843 |
1994 |
|
Nephroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Unlike the classic triphasic Wilms' tumor that contains blastema, stroma, and epithelial tubules, the anaplastic tumor expressed only marginal levels of insulin-like growth factor 2 (IGF-2) mRNA and imperceptible levels of the Wilms' tumor gene (WT-1), Pax-2, and Pax-8 mRNA.
|
8178926 |
1994 |