Secondary malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, CXCR4 and CCR7 expression was sharply reduced in liver metastases arising from intraocular melanomas.
|
18235009 |
2008 |
Secondary malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Diagnostic Value of Chemokine/Chemokine Receptor Pairs in Hepatocellular Carcinoma and Colorectal Liver Metastasis.
|
30633620 |
2019 |
Secondary malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Chemokine receptor CCR7 expression predicts poor outcome in uveal melanoma and relates to liver metastasis whereas expression of CXCR4 is not of clinical relevance.
|
24052640 |
2013 |
Secondary malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
While an overexpression of all the chemokine receptors was found in CRC, in colorectal liver metastases only the chemokine receptors CXCR4 and CCR6 were significantly upregulated.
|
16641550 |
2006 |
Secondary malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
In VIPoma, defects in the mismatch repair system especially in MSH2 may contribute to carcinogenesis, and increased CXCR4 may be associated with liver metastasis.
|
23231927 |
2012 |
Secondary malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results provide evidence showing that CXCR4 plays an important role in regulating biological functions associated with B16 liver metastasis.
|
28445180 |
2017 |
Secondary malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we investigate the possible role of SDF-1 (noncancerous liver tissue) and CXCR4 in liver metastases of colorectal cancer (CRC).
|
24238971 |
2014 |
Secondary malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The two cases of uveal melanoma liver metastases in our series showed CXCR4 expression, weak immunoreactivity for CXCL12 and absent VEGF immunostaining.
|
20036848 |
2010 |
Secondary malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, in order to uncover the role of CXCR4 during tumor cell/liver fibroblast crosstalk driving liver metastasis, the CXCR4 antagonist AMD3100 was used for in vitro studies and in an in vivo approach using an orthotopic model of liver metastasis in immune competent mice through intrasplenic injection of grafted C26 cells.
|
29436696 |
2018 |
Secondary malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present data suggest that there is a significant association between SDF-1/CXCR4 to enhance the liver metastases causing poor prognosis.
|
26406413 |
2015 |
Secondary malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CXCR4 expression was significantly higher in liver metastases (n = 39) compared with primary CRC tumors (n = 100; P < .0001).
|
15837989 |
2005 |
Secondary malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
KIT exon 11 557-558 deletion upregulates CXCR4 through increased binding of ETV1 to the CXCR4 promoter in GIST cells, which thus promotes liver metastasis.
|
26936919 |
2016 |
Secondary malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Microarray analysis identified CXCR4 as the most common CR expressed by both cancers. qRT demonstrated CXCR4 expression in 24 of 27 (89%) melanoma and 28 of 29 (97%) CRC liver metastases.
|
16794396 |
2006 |
Secondary malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The relationship between these two signaling pathways remains to be delineated in liver metastasis of colon cancer.<b>Methods</b>: Immunohistochemistry was employed to investigate CXCR4 expression in 45 human specimens of primary colorectal cancer (CRC) and liver metastasis.
|
31825725 |
2020 |
Secondary malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
On the 28th day after the operation, CRC growth and liver metastasis were assessed by morphology, the changes in the expression of HIF-1α (hypoxia inducible factor-1α), stromal cell-derived factor-1 alpha (SDF-1α), CXCR4 (C-X-C chemokine receptor type 4), PI3K, and Akt in the transplanted tumor and SDF-1α and CXCR4 in the liver were detected by Western blot and immunohistochemistry.
|
30789971 |
2019 |
Secondary malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expression of six genes was significantly different in primary tumors compared with their matched liver metastases [CXCR4 (p < 0.001), THBS1 (p = 0.007), MMP 9 (p = 0.048), GST Pi (p = 0.050), TYMP (p = 0.042) and DPYD (p < 0.001)].
|
25301403 |
2015 |
Secondary malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
CXCR4 is a potential therapeutic target for preventing the initial establishment of liver metastases but has limited application for use in advanced liver tumors.
|
19553629 |
2009 |
Secondary malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In our meta-analysis, C-X-C chemokine receptor type 4 expression is related to tumor-node-metastasis stage, tumor differentiation, liver metastasis, lymph node metastasis, distant metastasis, and diagnosis, and no correlation of C-X-C chemokine receptor type 4 expression with tumor size, gender, preoperative carcinoembryonic antigen, age, or vascular invasion has been observed.
|
28621237 |
2017 |
Secondary malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
In human specimens, the content of CD133(+)CXCR4(+) cells was higher in liver metastases than in primary colorectal tumors.
|
22871210 |
2012 |
Secondary malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
DC - SIGNR by influencing the lncRNA HNRNPKP2 upregulates the expression of CXCR4 in gastric cancer liver metastasis.
|
28403883 |
2017 |
Secondary malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry was performed to examine quantitatively the expression of CXCR4 in 40 human samples of colorectal cancer and liver metastasis.
|
19588204 |
2009 |
Secondary malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, treatment with sorafenib/MEK inhibitor-loaded CXCR4-targeted NPs significantly suppressed hepatic fibrosis progression and further prevented fibrosis-associated HCC development and liver metastasis.
|
29463989 |
2018 |
Secondary malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We analyzed 159 human CRC samples and found that expression of CXCR4 and αvβ6 was significantly associated with liver metastasis, and interestingly expression of αvβ6 significantly correlated with expression of CXCR4.
|
24085800 |
2014 |
Secondary malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Enhanced CXCR4 expression was detected in liver metastases resected from patients with colon cancer treated by the standard FOLFOX regimen.
|
20460542 |
2010 |
Secondary malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
The influence of lentivirus-mediated CXCR4 RNA interference on hepatic metastasis of colorectal cancer.
|
24647809 |
2014 |