CXCR4, C-X-C motif chemokine receptor 4, 7852

N. diseases: 739; N. variants: 23
Disease: Neuralgia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.350 Biomarker phenotype BEFREE Importantly, intervening with CXCL12/CXCR4 presents an effective therapeutic approach to treat the neuropathic pain. 30955244 2019
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.350 Biomarker phenotype BEFREE High mobility group box 1 protein (HMGB1) and Chemokine CXC receptor 4 (CXCR4) participate in neuropathic pain development. 30142543 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.350 Biomarker phenotype BEFREE Overexpression of miR-23a by intrathecal injection of miR-23a mimics or lentivirus reduced spinal CXCR4 and prevented pSNL-induced neuropathic pain. 29386025 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.350 Biomarker phenotype BEFREE CXCR4 antagonist can elicit analgesic effects and restore the inhibitory neurotransmission such as GlyRα3 against NP. 28919816 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.350 Biomarker phenotype BEFREE (1) IVF injection of ozone at L4-5 was only effective in suppression of mechanical allodynia in rats with neuropathic pain but not with inflammatory pain; (2) the analgesic effects of IVF ozone lasted much longer (> 14 days) than other selective molecular target drugs (< 48 hours) inhibiting or antagonizing at Nav1.8 (A-803467), CXCR4 (AMD3100), mTOR (rapamycin), and histone deacetylase (MGCD0103); (3) combined use of systemic gabapentin and IVF ozone produced a synergistic analgesic effect in rats with neuropathic pain. 28727712 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.350 Biomarker phenotype CTD_human CXCR4 chemokine receptor signaling mediates pain hypersensitivity in association with antiretroviral toxic neuropathy. 17292584 2007