|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients were classified into the following groups based on a review of medical records: (1) acute recurrent idiopathic pancreatitis (ARIP) with or without underlying chronic pancreatitis; (2) idiopathic chronic pancreatitis (ICP) without a history of ARP; (3) an unexplained first episode of acute pancreatitis (AP)<35 years of age; and (4) family history of pancreatitis.
|
28440306 |
2017 |
|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
MANF inhibits liver cancer via SUMOylation-related suppression of NF-κB/Snail signaling pathway and epithelial-mesenchymal transition.
|
31469428 |
2019 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, whether MANF exerts its protective effect against Aβ neurotoxicity in AD remains unknown.
|
30760285 |
2019 |
|
Atrial Fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
The serum MANF in patients with AF was markedly lower than that in patients with SR, which was inversely correlated with atrial apoptosis in patients with AF.
|
31789884 |
2020 |
|
Autoimmune Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Of them 12 are associated with other autoimmune diseases than SLE, whereas three genes (ZNF804A, CDK1, and MANF) have not previously been associated with autoimmunity.
|
28740209 |
2017 |
|
Autoimmune Diseases
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Here, we determined that ER stress inducible protein Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) was up-regulated in autoimmune diseases and inflammatory disease models.
|
25640174 |
2015 |
|
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
MANF was mainly expressed in rat neurons, and its expression increased significantly at 3 h after SAH induction and peaked at 24 h. Stereotactic injection of rh-MANF into the cerebroventricle significantly increased the level of MANF, p-Akt, p-mouse double minute 2 homolog (p-MDM2), and B-cell lymphoma 2 (Bcl-2) in brain tissue, whereas it down-regulated the expression of P53, Bcl-2-associated X protein (Bax), and cleaved caspase-3, which indicated that neuronal apoptosis was remarkably suppressed.
|
30211660 |
2019 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We constructed a set of lentiviral vectors that contain or lack the highly conserved final four amino acids of MANF ("RTDL"), which resemble the canonical ER retention signal ("KDEL"), to study MANF regulation in neuroblastoma cells and rat primary cortical neurons.
|
23255601 |
2013 |
|
Cerebral Infarction
|
0.030 |
Biomarker
|
disease |
BEFREE |
Many groups, including ours, have proved that MANF rescues neuronal loss in several neurological disorders, such as Parkinson's disease and cerebral ischemia.
|
30760285 |
2019 |
|
Cerebral Infarction
|
0.030 |
Biomarker
|
disease |
BEFREE |
The more interesting results in this study were that MANF repressed the cleavage of caspase-3 triggered by focal cerebral ischemia.
|
25001514 |
2014 |
|
Cerebral Infarction
|
0.030 |
Biomarker
|
disease |
BEFREE |
Effects of mesencephalic astrocyte-derived neurotrophic factor on cerebral angiogenesis in a rat model of cerebral ischemia.
|
31785307 |
2020 |
|
Cerebrovascular accident
|
0.040 |
Biomarker
|
group |
BEFREE |
In this study, we examined the protective effect of adeno-associated virus serotype 7 encoding MANF in a rodent model of stroke.
|
20685313 |
2010 |
|
Cerebrovascular accident
|
0.040 |
Biomarker
|
group |
BEFREE |
The beneficial effect of MANF treatment on the reversal of stroke-induced behavioral deficits implies that MANF-based therapies could be used for the repair of brain tissue after stroke.
|
29806020 |
2018 |
|
Cerebrovascular accident
|
0.040 |
Biomarker
|
group |
BEFREE |
Recombinant human MANF was administered intracerebroventricularly 24 h after stroke.
|
31785307 |
2020 |
|
Cerebrovascular accident
|
0.040 |
Biomarker
|
group |
BEFREE |
MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke.
|
29050872 |
2018 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We constructed a set of lentiviral vectors that contain or lack the highly conserved final four amino acids of MANF ("RTDL"), which resemble the canonical ER retention signal ("KDEL"), to study MANF regulation in neuroblastoma cells and rat primary cortical neurons.
|
23255601 |
2013 |
|
Chronic atrial fibrillation
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that MANF down-regulation may lead to more atrial apoptosis in human chronic AF, indicating MANF as a potential therapeutic agent in AF treatment.
|
31789884 |
2020 |
|
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure.
|
20970425 |
2011 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Circulating MANF concentrations were significantly higher in PD patients compared to controls (<i>P</i> < 0.001) and were positively correlated with Beck Depression Inventory (BDI) depression rating.
|
31555085 |
2019 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Circulating MANF concentrations were significantly higher in PD patients compared to controls (<i>P</i> < 0.001) and were positively correlated with Beck Depression Inventory (BDI) depression rating.
|
31555085 |
2019 |
|
Diabetes
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here we will discuss the structural motifs and physiological functions of CDNF and MANF as well as their therapeutic potential for the treatment of neurodegenerative diseases and diabetes.
|
27425895 |
2017 |
|
Diabetes
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, increased MANF levels has been detected in the sera of young children with newly diagnosed Type 1 (T1D) diabetes and Type 2 (T2D) diabetic patients.
|
30386256 |
2018 |
|
Diabetes
|
0.030 |
Biomarker
|
disease |
BEFREE |
Recent studies in rodent models have demonstrated that MANF mitigates diabetes, exerts neurotrophic function in neurodegenerative disease, protects cardiomyocytes and neurons in myocardial infarction and cerebral ischemia, respectively, and promotes immune cell phenotype switch from proinflammatory macrophages to prorepair anti-inflammatory macrophages.
|
28719799 |
2017 |
|
Diabetes Mellitus
|
0.030 |
Biomarker
|
group |
BEFREE |
Here we will discuss the structural motifs and physiological functions of CDNF and MANF as well as their therapeutic potential for the treatment of neurodegenerative diseases and diabetes.
|
27425895 |
2017 |
|
Diabetes Mellitus
|
0.030 |
Biomarker
|
group |
BEFREE |
Recent studies in rodent models have demonstrated that MANF mitigates diabetes, exerts neurotrophic function in neurodegenerative disease, protects cardiomyocytes and neurons in myocardial infarction and cerebral ischemia, respectively, and promotes immune cell phenotype switch from proinflammatory macrophages to prorepair anti-inflammatory macrophages.
|
28719799 |
2017 |