|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
CLINVAR |
|
|
|
|
Abnormal delivery
|
0.100 |
GeneticVariation
|
phenotype |
CLINVAR |
|
|
|
|
Abnormal muscle tone
|
0.100 |
GeneticVariation
|
phenotype |
CLINVAR |
|
|
|
|
Acute lymphocytic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Functional analyses suggested this T-ALL risk allele is located in a putative cis-regulatory DNA element with negative effects on USP7 transcription.
|
30938820 |
2019 |
|
Adenocarcinoma
|
0.040 |
AlteredExpression
|
group |
BEFREE |
In addition, upregulation of MLL5 expression was correlated with increased expression of OGT and USP7 in human primary cervical adenocarcinomas.
|
26678539 |
2015 |
|
Adenocarcinoma
|
0.040 |
Biomarker
|
group |
LHGDN |
Expression and functional analyses of mHAUSP regulating apoptosis of cervical adenocarcinoma cells.
|
15942648 |
2005 |
|
Adenocarcinoma
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Concerning tumour histology, HAUSP mRNA expression was significantly lower in adenocarcinomas than in squamous cell carcinomas (p = 0.0038), while the frequency of p53 mutation was significantly higher in squamous cell carcinomas than in adenocarcinomas (p = 0.0461).
|
16450335 |
2006 |
|
Adenocarcinoma
|
0.040 |
Biomarker
|
group |
BEFREE |
Then, the prognostic role of USP7 was analyzed in 110 NSCLC samples (excluding the adenocarcinoma).
|
25519684 |
2015 |
|
Adenomatous Polyposis Coli
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, the Wnt-activating role of USP7 is specific to APC mutations; thus, it can be used as a tumor-specific therapeutic target for most CRCs.
|
29045831 |
2017 |
|
Adult Acute Lymphocytic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Functional analyses suggested this T-ALL risk allele is located in a putative cis-regulatory DNA element with negative effects on USP7 transcription.
|
30938820 |
2019 |
|
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Stabilization of LSD1 by deubiquitinating enzyme USP7 promotes glioblastoma cell tumorigenesis and metastasis through suppression of the p53 signaling pathway.
|
27632941 |
2016 |
|
Adult Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings suggest that Usp7 is important for MB cell proliferation and metastasis by activating Shh pathway, and is a putative therapeutic target for MBs.
|
28137592 |
2017 |
|
Anxiety
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Atrial Premature Complexes
|
0.010 |
Biomarker
|
disease |
BEFREE |
USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination.
|
29045831 |
2017 |
|
Autism Spectrum Disorders
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Haploinsufficiency of USP7, located at chromosome 16p13.2, has recently been reported in seven individuals with neurodevelopmental phenotypes, including developmental delay/intellectual disability (DD/ID), autism spectrum disorder (ASD), seizures, and hypogonadism.
|
30679821 |
2019 |
|
Autism Spectrum Disorders
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Importantly, we identify de novo heterozygous loss-of-function mutations of USP7 in individuals with a neurodevelopmental disorder, featuring intellectual disability and autism spectrum disorder.
|
26365382 |
2015 |
|
Autonomic bladder dysfunction
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Bladder Neoplasm
|
0.310 |
Biomarker
|
disease |
BEFREE |
In high grade UBC the identification of two clusters of patients based on CCDC6 and USP7 expession can possibly indicate the use of PARP-inhibitor drugs, in combination with USP7 inhibitor in addition to the DNA damage inducer RRx-001, that also acts as an immunomodulatory agent, offering novel therapeutic strategy for personalized medicine in bladder cancer patients.
|
30786932 |
2019 |
|
Bladder Neoplasm
|
0.310 |
Biomarker
|
disease |
CTD_human |
Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer.
|
26039340 |
2015 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
USP7 was overexpressed in breast carcinomas, and the level of expression positively correlated with expression of PHF8 and cyclin A2 and with the histological grade of breast cancer.
|
27183383 |
2016 |
|
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accordingly, depletion of USP7 impaired the engagement of the MRN-MDC1 complex and the consequent recruitment of the downstream factors p53-binding protein 1 (53BP1) and breast cancer protein 1 (BRCA1) at DNA lesions.
|
30179224 |
2018 |
|
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Correction: DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer.
|
31068665 |
2019 |
|
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer.
|
28288134 |
2017 |
|
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer.
|
28650472 |
2017 |