|
Malignant neoplasm of breast
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Rheumatoid Arthritis
|
0.130 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
|
21156761 |
2011 |
|
Rheumatoid Arthritis
|
0.130 |
GeneticVariation
|
disease |
GWASDB |
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
|
17804836 |
2007 |
|
Rheumatoid Arthritis
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
Since the QKRAA/QRRAA epitope does not provide any risk for disease susceptibility in RA-susceptibility DRB1 epitope-negative patients, the present data suggest that the class III region haplotype D6S273 138-HSP70c-Bat2 138-TNFa2 provides an additional risk for the development of RA.
|
10949724 |
2000 |
|
Rheumatoid Arthritis
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
The results demonstrate that two regions in MHC, class II (DRbeta1) and class III (D6S273, HSP70, Bat2, TNFa) more completely define the risk for development of RA.
|
10604236 |
1999 |
|
Rheumatoid Arthritis
|
0.130 |
Biomarker
|
disease |
BEFREE |
Since these associations between DRB1 genes and susceptibility to RA are incomplete, we examined the role of a CA repeat polymorphic microsatellite marker, D6S273, located between HSP70 and Bat2 genes in the class III region of MHC, in susceptibility to RA.
|
9820598 |
1998 |
|
Rheumatoid Arthritis
|
0.130 |
GeneticVariation
|
disease |
GWASDB |
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
|
19503088 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
These different alleles associated with T1D were not independent and we observed linkage disequilibrium among them leading us to describe two new risk haplotypes (DQA1*0101-DQB1*0501-TNFa2b1 and DQA1*0201-DQB1*0202- BAT-2*2).
|
15842729 |
2005 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the BAT2 microsatellite polymorphism is associated with the age-at-onset of IDDM and possibly with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM.
|
10987645 |
1999 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.120 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
|
17632545 |
2007 |
|
Ulcerative Colitis
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
The allelic combination DRB1*0103/D6S273-5/BAT_2-8/TNFa11b4c1d3e3/IKBL+738(C)/MICA5.1 that includes the telomeric class III markers of the 7.1 ancestral haplotype is highly increased in patients with UC (P=0.0001, OR=10.57), especially in those with the extensive form of the disease (P=0.02, OR=3.41 extensive versus distal).
|
16116311 |
2005 |
|
Ulcerative Colitis
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association scan in north Indians reveals three novel HLA-independent risk loci for ulcerative colitis.
|
24837172 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
|
24871463 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.110 |
Biomarker
|
disease |
BEFREE |
In conclusions, it cannot be excluded that the BAT2/RsaI 2.7-kb band may contribute to the susceptibility to PBC, pSS, and SLE.
|
1672123 |
1991 |
|
Schizophrenia
|
0.110 |
Biomarker
|
disease |
BEFREE |
With this data-driven weighting procedure the LRT detected significant signal in genes located in regions already confirmed as associated with schizophrenia - the PRRC2A (p = 1.020e-06) and the VARS2 (p = 2.383e-06) - in the Swedish schizophrenia case-control cohort of 11,040 individuals with exome-sequencing data.
|
28238293 |
2017 |
|
Schizophrenia
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
|
28540026 |
2017 |
|
Membranous glomerulonephritis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.
|
21323541 |
2011 |
|
Hodgkin Disease
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma.
|
24149102 |
2013 |
|
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
Myasthenia Gravis
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08.
|
23055271 |
2012 |
|
Takayasu Arteritis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study.
|
25604533 |
2015 |
|
Major Depressive Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways.
|
29662059 |
2018 |
|
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
|
21051598 |
2010 |
|
Obesity
|
0.020 |
Biomarker
|
disease |
BEFREE |
Odds ratios for obesity ranged from 1.46 (95% confidence interval (CI): 1.12, 1.92) for BAT2 to 2.16 (95% CI: 1.39, 3.37) for MC4R.
|
20616199 |
2010 |
|
Obesity
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Of five studied variants, only two (SEC16B rs10913469, SH2B1 rs4788102) were nominally associated with indices of adiposity and obesity risk in girls and only SEC16B rs10913469 in children at puberty (p < 0·05), while no statistical associations was found for three other variants (PCSK1rs6235, KCTD15 rs29941, BAT2 rs2844479).
|
23121087 |
2013 |