|
Rheumatoid Arthritis
|
0.130 |
GeneticVariation
|
disease |
GWASDB |
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
|
17804836 |
2007 |
|
Rheumatoid Arthritis
|
0.130 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of BAT1 mRNA was associated with carriers of a haplotype containing the LST1 marker transmitted to RA cases in a family study and also DRB1(*)15 associated with susceptibility to nephritis in systemic lupus erythematosus.
|
16971954 |
2006 |
|
Rheumatoid Arthritis
|
0.130 |
Biomarker
|
disease |
LHGDN |
BAT1 promoter polymorphism is associated with rheumatoid arthritis susceptibility.
|
18381799 |
2008 |
|
Rheumatoid Arthritis
|
0.130 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
|
21156761 |
2011 |
|
Rheumatoid Arthritis
|
0.130 |
GeneticVariation
|
disease |
GWASDB |
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
|
19503088 |
2009 |
|
Rheumatoid Arthritis
|
0.130 |
Biomarker
|
disease |
BEFREE |
The role of BAT1 in the regulation of tumor necrosis factor-a suggests that BAT1 may regulate the inflammatory response observed in patients with RA.
|
18381799 |
2008 |
|
Rheumatoid Arthritis
|
0.130 |
Biomarker
|
disease |
BEFREE |
In this critical segment, four expressed genes have been thus far identified, NFKBIL1 (IkappaBL), ATP6G, BAT1, and MICB, all of which are candidate genes for determining susceptibility to RA.
|
11170743 |
2001 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.120 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
|
17632545 |
2007 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.120 |
Biomarker
|
disease |
BEFREE |
BAT1 belongs to the DEAD-box family of proteins, and is encoded in the central region of the MHC, a region containing genes affecting immunopathological disorders including Type 1 diabetes.
|
12653967 |
2003 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
DNA samples from healthy donors were used to confirm haplotypic associations with the type 1 diabetes-susceptible 8.1 ancestral haplotype (AH; HLA-A1,B8,BAT1-22*C,BAT1-348*C,DR3 ) and the diabetes-resistant 7.1 AH (HLA-A3,B7,BAT1-22*G,BAT1-348*T,DR15).
|
15028669 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
[Genome-wide association study of allergic diseases in Russians of Western Siberia].
|
21790008 |
2011 |
|
Dermatitis, Atopic
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis.
|
23886662 |
2013 |
|
Toxic Epidermal Necrolysis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients.
|
21912425 |
2013 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Identification of independent risk loci for Graves' disease within the MHC in the Japanese population.
|
21900946 |
2011 |
|
Myositis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes.
|
26291516 |
2015 |
|
Stevens-Johnson Syndrome
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients.
|
21912425 |
2013 |
|
Stevens-Johnson Syndrome
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients.
|
21912425 |
2013 |
|
Vitiligo
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.
|
20526339 |
2010 |
|
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Common genetic variation and the control of HIV-1 in humans.
|
20041166 |
2009 |
|
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
|
21051598 |
2010 |
|
Myocardial Infarction
|
0.030 |
GeneticVariation
|
disease |
LHGDN |
The most abundant 9-marker haplotype of the BAT1-NFKBIL1-LTA region, named haplotype 1 (28% frequency in the study population), included the alleles of the five protective genotypes and was related with a significantly lower risk of myocardial infarction (OR 0.88, 95% CI 0.80-0.98; P = 0.015).
|
17517687 |
2007 |
|
Myocardial Infarction
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The most abundant 9-marker haplotype of the BAT1-NFKBIL1-LTA region, named haplotype 1 (28% frequency in the study population), included the alleles of the five protective genotypes and was related with a significantly lower risk of myocardial infarction (OR 0.88, 95% CI 0.80-0.98; P = 0.015).
|
17517687 |
2007 |
|
Myocardial Infarction
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Multiple single-nucleotide polymorphisms in the BAT1-NFKBIL1-LTA region on the short arm of chromosome 6 have been found to be associated with susceptibility to myocardial infarction in a recent case-control study including individuals from Japan.
|
15843211 |
2005 |
|
Myocardial Infarction
|
0.030 |
Biomarker
|
disease |
BEFREE |
Subsequent linkage-disequilibrium (LD) mapping and analyses of haplotype structure showed significant associations between myocardial infarction and a single 50 kb halpotype comprised of five SNPs in LTA (encoding lymphotoxin-alpha), NFKBIL1 (encoding nuclear factor of kappa light polypeptide gene enhancer in B cells, inhibitor-like 1) and BAT1 (encoding HLA-B associated transcript 1).
|
12426569 |
2002 |
|
Leprosy
|
0.020 |
Biomarker
|
disease |
BEFREE |
Interaction analysis between PARK2 and significant SNPs of anti-inflammatory/proinflammatory cytokine genes, including BAT1 to BTNL2-DR spanning the HLA (6p21.3) region in a case-control comparison, showed that the combined analysis of: (1) PARK2, tumour necrosis factor (TNF), BTNL2-DR, interleukin (IL)-10, IL-6 and TGFBR2 increased the risk towards leprosy (OR=2.54); (2) PARK2, BAT1, NFKBIL1, LTA, TNF-LTB, IL12B and IL10RB provided increased protection (OR=0.26) in comparison with their individual contribution.
|
24578538 |
2014 |