|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The odds ratios (OR) showed that IRX3 rs3751723 was associated with risk of obesity in additive model (p=0.017), recessive model (p=0.016) and with high BF% in all models.
|
30713021 |
2020 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bioinformatics tools were used to evaluate the correlations between hypothalamic Irx3 and neurotransmitters, markers of thermogenesis and obesity related phenotypes.
|
30522931 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IRX3 expression has been functionally associated in obesity-associated long-distance susceptibility loci, but the effect of the IRX3 genetic variants on human obesity and obesity-related metabolism remains uncertain.
|
28316138 |
2018 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The Iroquois homeodomain transcription factor gene IRX3 is expressed in the developing nervous system, limb buds, and heart, and transcript levels specify obesity risk in humans.
|
29346763 |
2018 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The analysis of the FTO-IRX3 locus revealed high LD and high order gene-gene interactions for BMI linked obesity.
|
27650258 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
We aimed to test IRX3's roles in the browning program and to evaluate the association between the genetic variants in IRX3 and human obesity.
|
28988979 |
2017 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This is the first study to reveal that genetic variants of both FTO and IRX3 genes are in high linkage disequilibrium (LD) and are associated with obesity risk in North Indians.
|
26440677 |
2016 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
It has been recently suggested that although the obesity related SNPs reside in the first intron of FTO, they may not only impact FTO but mediate their obesity effects via nearby genes (notably RPGRIP1L and IRX3).
|
26627093 |
2015 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Consistent with this, obesity-associated single nucleotide polymorphisms are associated with expression of IRX3, but not FTO, in human brains.
|
24646999 |
2014 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genomewide association studies (GWAS) have indicated that SNPs on a chromosome 16 locus encompassing FTO, as well as IRX3, 5, 6, FTM and FTL are robustly associated with human obesity.
|
25224490 |
2014 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Knockdown of its orthologue in zebrafish, irx3a, increased the number of pancreatic ghrelin-producing epsilon cells and decreased the number of insulin-producing beta-cells and glucagon-producing alpha-cells, thereby suggesting a direct link of pancreatic IRX3 function to both obesity and type 2 diabetes.
|
20080751 |
2010 |